Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 10/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.46 |
| ▸ | LTA4H | P09960 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | FDPS | P14324 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9732387 | 0.81 | CYP2A6 (0.49) | TBXAS1CYP3A4LTA4HCYP2A6 | |
| SCHEMBL9732450 | 0.78 | TBXAS1 (0.81) | TBXAS1 | |
| SCHEMBL10972402 | 0.77 | TBXAS1 (0.68) | TBXAS1LTA4HMAPTCYP2A6 | |
| SCHEMBL6642413 | 0.76 | TBXAS1 (0.68) | TBXAS1CYP3A4LTA4HMAPTCYP2A6 | |
| SCHEMBL6642146 | 0.76 | TBXAS1 (0.68) | TBXAS1CYP3A4LTA4HMAPTCYP2A6 | |
| SCHEMBL6642234 | 0.76 | TBXAS1 (0.60) | TBXAS1LTA4HMAPTCYP2A6 | |
| SCHEMBL9732228 | 0.75 | TBXAS1 (0.49) | TBXAS1LTA4H | |
| SCHEMBL9732407 | 0.75 | TBXAS1 (0.52) | TBXAS1CYP3A4LTA4HMAPTRECQL | |
| Hydrochloric Acid SCHEMBL9732219 | 0.74 | TBXAS1 (0.52) | TBXAS1 | |
| SCHEMBL14407352 | 0.74 | PPARG (0.54) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5153214-A | Treating cardiovascular disorders | CIBA-GEIGY CORPORATION (US) | 1992-10-06 | — | — | US | disclosed |
| US-5025025-A | Cardiovascular disorders | CIBA-GEIGY CORPORATION (US) | 1991-06-18 | — | — | US | disclosed |
| EP-0405391-A1 | Certain (arylsulfonamido- and pyridyl- or imidazolyl-)-substituted carboxylic acids and derivatives thereof | CIBA-GEIGY AG (CH) | 1991-01-02 | — | — | EP | disclosed |