Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 10/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | REN | P00797 | 1/20 | 0.37 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5806086 | 1.00 | ACE (0.45) | ACELMNAMEN1KMT2AUSP2 | |
| SCHEMBL6508290 | 1.00 | ACE (0.45) | ACELMNAMEN1KMT2AUSP2 | |
| SCHEMBL9731804 | 1.00 | ACE (0.45) | ACELMNAMEN1KMT2AUSP2 | |
| SCHEMBL5794084 | 0.92 | ACE (0.48) | ACELMNAMEN1KMT2AUSP2 | |
| SCHEMBL9520888 | 0.92 | ACE (0.48) | ACELMNAMEN1KMT2AUSP2 | |
| SCHEMBL9731888 | 0.92 | ACE (0.44) | ACELMNAMEN1KMT2AUSP2 | |
| SCHEMBL9863834 | 0.80 | ACE (0.42) | ACELMNASMN1; SMN2 | |
| SCHEMBL10735598 | 0.78 | ACE (0.35) | ACELMNAMEN1KMT2AUSP2 | |
| SCHEMBL10742800 | 0.78 | ACE (0.35) | ACELMNAMEN1KMT2AUSP2 | |
| SCHEMBL10787640 | 0.77 | ACE (0.38) | ACELMNAMEN1KMT2AUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5101039-A | Carboxyindoles, hypotensive agents, inhibitors of angiotensin converting enzyme | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-03-31 | — | — | US | disclosed |
| US-5008400-A | Chemical intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-04-16 | — | — | US | disclosed |
| US-4933361-A | HYPOTENSIVE AGENTS | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-06-12 | — | — | US | disclosed |