Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 10/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.39 |
| ▸ | REN | P00797 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9520888 | 1.00 | ACE (0.48) | ACEMEN1KMT2ALMNAUSP2 | |
| SCHEMBL5806086 | 0.92 | ACE (0.45) | ACEMEN1KMT2ALMNAUSP2 | |
| SCHEMBL9731804 | 0.92 | ACE (0.45) | ACEMEN1KMT2ALMNAUSP2 | |
| SCHEMBL9733291 | 0.92 | ACE (0.45) | ACEMEN1KMT2ALMNAUSP2 | |
| SCHEMBL6508290 | 0.92 | ACE (0.45) | ACEMEN1KMT2ALMNAUSP2 | |
| SCHEMBL9731888 | 0.91 | ACE (0.44) | ACEMEN1KMT2ALMNAUSP2 | |
| SCHEMBL10460483 | 0.84 | ACE (0.40) | ACEMEN1KMT2ALMNAUSP2 | |
| SCHEMBL9733499 | 0.84 | ACE (0.40) | ACEMEN1KMT2ALMNAUSP2 | |
| Hydrochloric Acid SCHEMBL10741835 | 0.83 | ACE (0.40) | ACEMEN1KMT2ALMNAUSP2 | |
| Hydrochloric Acid SCHEMBL9732651 | 0.83 | ACE (0.40) | ACEMEN1KMT2ALMNAUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006014916-A2 | PREPARATION OF TRANDOLAPRIL | DR. REDDY'S LABORATORIES LTD. (IN) | 2006-02-09 | — | — | WO | claimed |
| EP-1663973-A1 | 2-PYRIDONE DERIVATIVES AS NEUTROPHIL ELASTASE INHIBITORS AND THEIR USE | AstraZeneca AB (SE) | 2006-06-07 | — | — | EP | disclosed |
| WO-2006014916-A2 | PREPARATION OF TRANDOLAPRIL | DR. REDDY'S LABORATORIES LTD. (IN) | 2006-02-09 | — | — | WO | disclosed |
| WO-2005026123-A1 | 2-PYRIDONE DERIVATIVES AS NEUTROPHIL ELASTASE INHIBITORS AND THEIR USE | ASTRAZENECA AB (SE) | 2005-03-24 | — | — | WO | disclosed |