Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR2 | Q9NS75 | 17/20 | 0.62 |
| ▸ | CYSLTR1 | Q9Y271 | 17/20 | 0.62 |
| ▸ | PPARG | P37231 | 2/20 | 0.62 |
| ▸ | PPARD | Q03181 | 2/20 | 0.62 |
| ▸ | PPARA | Q07869 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.62 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.62 |
| ▸ | BLM | P54132 | 1/20 | 0.62 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9733764 | 0.90 | PPARG (0.63) | CYSLTR2CYSLTR1PPARGPPARDPPARA | |
| SCHEMBL9733643 | 0.88 | CYSLTR2 (0.57) | CYSLTR2CYSLTR1PPARGPPARDPPARA | |
| SCHEMBL9733661 | 0.87 | GRM2 (0.75) | CYSLTR2CYSLTR1PPARGPPARDPPARA | |
| SCHEMBL9733479 | 0.87 | CYSLTR2 (0.59) | CYSLTR2CYSLTR1PPARGPPARDPPARA | |
| SCHEMBL9733466 | 0.84 | CYSLTR1 (0.62) | CYSLTR2CYSLTR1PPARGPPARDPPARA | |
| SCHEMBL9734152 | 0.83 | CYSLTR2 (0.46) | CYSLTR2CYSLTR1PPARGPPARDPPARA | |
| SCHEMBL9638148 | 0.81 | CYSLTR2 (0.60) | CYSLTR2CYSLTR1PPARGPPARDPPARA | |
| SCHEMBL9733554 | 0.78 | CYSLTR2 (0.70) | CYSLTR2CYSLTR1PPARGPPARDPPARA | |
| SCHEMBL9157243 | 0.78 | CYSLTR2 (0.80) | CYSLTR2CYSLTR1PPARGPPARDPPARA | |
| SCHEMBL2354985 | 0.78 | CYSLTR2 (0.58) | CYSLTR2CYSLTR1PPARGPPARDPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5135940-A | Antiallegens, antiinflammatory agents | MERCK FROSST CANADA, INC. (CA) | 1992-08-04 | — | — | US | disclosed |
| EP-0252639-A1 | Leukotriene antagonists | MERCK FROSST CANADA INC. (CA) | 1988-01-13 | — | — | EP | disclosed |
| EP-0104885-B1 | LEUKOTRIENE ANTAGONISTS, THEIR PRODUCTION, AND COMPOSITIONS CONTAINING THEM | MERCK FROSST CANADA INC. (CA) | 1986-06-04 | — | — | EP | disclosed |
| EP-0156233-A2 | Use of leukotriene antagonists for producing cytoprotective pharmaceutical compositions and process for producing cytoprotective pharmaceutical compositions | MERCK & CO. INC. (US) | 1985-10-02 | — | — | EP | disclosed |
| EP-0104885-A1 | Leukotriene antagonists, their production, and compositions containing them | MERCK FROSST CANADA INC. (CA) | 1984-04-04 | — | — | EP | disclosed |