Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR2 | Q9NS75 | 15/20 | 0.65 |
| ▸ | CYSLTR1 | Q9Y271 | 15/20 | 0.65 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.52 |
| ▸ | PPARG | P37231 | 2/20 | 0.49 |
| ▸ | PPARD | Q03181 | 2/20 | 0.49 |
| ▸ | PPARA | Q07869 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9734563 | 0.91 | CYSLTR2 (0.73) | CYSLTR2CYSLTR1GRM2PPARGPPARD | |
| SCHEMBL9734317 | 0.90 | CYSLTR2 (0.64) | CYSLTR2CYSLTR1GRM2PPARGPPARD | |
| SCHEMBL9734313 | 0.90 | CYSLTR2 (0.72) | CYSLTR2CYSLTR1GRM2PPARGPPARD | |
| SCHEMBL9734570 | 0.88 | CYSLTR2 (0.62) | CYSLTR2CYSLTR1GRM2PPARGPPARD | |
| SCHEMBL10891172 | 0.87 | CYSLTR2 (0.69) | CYSLTR2CYSLTR1GRM2PPARGPPARD | |
| SCHEMBL10698797 | 0.87 | CYSLTR2 (0.69) | CYSLTR2CYSLTR1GRM2PPARGPPARD | |
| SCHEMBL10698768 | 0.85 | CYSLTR2 (0.56) | CYSLTR2CYSLTR1GRM2PPARGPPARD | |
| SCHEMBL9734285 | 0.84 | CYSLTR2 (0.83) | CYSLTR2CYSLTR1GRM2PPARGPPARD | |
| SCHEMBL9733456 | 0.83 | CYSLTR2 (0.70) | CYSLTR2CYSLTR1GRM2PPARGPPARD | |
| SCHEMBL9733535 | 0.83 | CYSLTR2 (0.72) | CYSLTR2CYSLTR1GRM2PPARGPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0252639-A1 | Leukotriene antagonists | MERCK FROSST CANADA INC. (CA) | 1988-01-13 | — | — | EP | claimed |
| EP-0106565-B1 | LEUKOTRIENE ANTAGONISTS, THEIR PRODUCTION, AND COMPOSITIONS CONTAINING THEM | MERCK FROSST CANADA INC. (CA) | 1986-09-10 | — | — | EP | claimed |
| EP-0106565-A1 | Leukotriene antagonists, their production, and compositions containing them | MERCK FROSST CANADA INC. (CA) | 1984-04-25 | — | — | EP | claimed |
| US-5135940-A | Antiallegens, antiinflammatory agents | MERCK FROSST CANADA, INC. (CA) | 1992-08-04 | — | — | US | disclosed |
| EP-0252639-A1 | Leukotriene antagonists | MERCK FROSST CANADA INC. (CA) | 1988-01-13 | — | — | EP | disclosed |
| EP-0106565-B1 | LEUKOTRIENE ANTAGONISTS, THEIR PRODUCTION, AND COMPOSITIONS CONTAINING THEM | MERCK FROSST CANADA INC. (CA) | 1986-09-10 | — | — | EP | disclosed |
| EP-0106565-A1 | Leukotriene antagonists, their production, and compositions containing them | MERCK FROSST CANADA INC. (CA) | 1984-04-25 | — | — | EP | disclosed |