Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 8/20 | 0.64 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | BLM | P54132 | 1/20 | 0.56 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.56 |
| ▸ | DRD4 | P21917 | 1/20 | 0.56 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.56 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9734208 | 1.00 | OPRK1 (0.64) | OPRK1UTS2RNPC1CYP1A2CYP3A4 | |
| SCHEMBL9734204 | 1.00 | OPRK1 (0.64) | OPRK1UTS2RNPC1CYP1A2CYP3A4 | |
| SCHEMBL9515474 | 0.87 | OPRK1 (0.80) | OPRK1UTS2RNPC1CYP1A2CYP3A4 | |
| SCHEMBL9734040 | 0.82 | OPRK1 (0.56) | OPRK1NPC1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL9734046 | 0.82 | OPRK1 (0.56) | OPRK1NPC1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL9734042 | 0.82 | OPRK1 (0.56) | OPRK1NPC1CYP1A2CYP3A4CYP2D6 | |
| Fumaric Acid SCHEMBL9734432 | 0.82 | OPRK1 (0.71) | OPRK1UTS2RNPC1CYP1A2CYP3A4 | |
| Maleic Acid SCHEMBL9734427 | 0.82 | OPRK1 (0.71) | OPRK1UTS2RNPC1CYP1A2CYP3A4 | |
| SCHEMBL10514358 | 0.79 | OPRK1 (0.78) | OPRK1NPC1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL9514408 | 0.78 | OPRK1 (1.00) | OPRK1UTS2RNPC1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5114945-A | Spiropiperidine derivatives | GLAXO GROUP LIMITED (GB) | 1992-05-19 | — | — | US | disclosed |
| EP-0330461-A2 | Piperidine derivatives | GLAXO GROUP LIMITED (GB) | 1989-08-30 | — | — | EP | disclosed |