Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | MITF | O75030 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | FKBP1A | P62942 | 4/20 | 0.45 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.45 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.45 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.45 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.45 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.45 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | PREP | P48147 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8658861 | 0.83 | HTR2C (0.53) | HTTMITFMAPTPSEN1PSEN2 | |
| SCHEMBL757756 | 0.83 | HTR2C (0.53) | HTTMITFMAPTPSEN1PSEN2 | |
| SCHEMBL21326091 | 0.81 | PSEN1 (0.46) | HTTMITFMAPTPSEN1PSEN2 | |
| SCHEMBL3076603 | 0.81 | PSEN1 (0.46) | HTTMITFMAPTPSEN1PSEN2 | |
| SCHEMBL13634009 | 0.80 | PSEN1 (0.46) | HTTMITFMAPTPSEN1PSEN2 | |
| SCHEMBL3950322 | 0.79 | PSEN1 (0.53) | HTTMITFMAPTPSEN1PSEN2 | |
| SCHEMBL3159251 | 0.79 | P2RX7 (0.49) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL20449200 | 0.79 | P2RX7 (0.49) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL31462845 | 0.79 | MAPT (0.47) | HTTMITFMAPTPSEN1PSEN2 | |
| SCHEMBL2300448 | 0.78 | POLB (0.52) | HTTMITFMAPTFKBP1APSEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5114945-A | Spiropiperidine derivatives | GLAXO GROUP LIMITED (GB) | 1992-05-19 | — | — | US | disclosed |
| EP-0330461-A2 | Piperidine derivatives | GLAXO GROUP LIMITED (GB) | 1989-08-30 | — | — | EP | disclosed |