Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 2/20 | 0.58 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | PGR | P06401 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9222163 | 0.90 | MAPT (0.59) | PTGS1PTGS2SMN1; SMN2RAB9AALDH1A1 | |
| SCHEMBL11179898 | 0.85 | AKR1B1 (0.54) | AKR1B1MAPK14SMN1; SMN2RAB9AALDH1A1 | |
| Water SCHEMBL10842921 | 0.83 | MAPT (0.52) | SMN1; SMN2RAB9AALDH1A1MAPTKMT2A | |
| SCHEMBL11834532 | 0.81 | AKR1B1 (0.68) | AKR1B1MAPK14PTGS1PTGS2SMN1; SMN2 | |
| SCHEMBL12726875 | 0.79 | AKR1C3 (0.59) | AKR1B1PTGS1PTGS2SMN1; SMN2ALDH1A1 | |
| SCHEMBL12726876 | 0.79 | AKR1B1 (0.54) | AKR1B1PTGS1PTGS2SMN1; SMN2TP53 | |
| SCHEMBL9210700 | 0.79 | ALDH1A1 (0.58) | SMN1; SMN2RAB9AALDH1A1MAPTKMT2A | |
| SCHEMBL15195012 | 0.78 | PTGS1 (0.51) | AKR1B1PTGS1PTGS2ALDH1A1MAPT | |
| SCHEMBL11189383 | 0.78 | MAPT (0.60) | AKR1B1MAPK14SMN1; SMN2RAB9AALDH1A1 | |
| SCHEMBL12726878 | 0.77 | AKR1C3 (0.58) | AKR1B1PTGS1PTGS2SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-55000377-A | — | — | None | — | — | JP | disclosed |
| US-5175286-A | Antiphlogistic agent | HISAMITSU PHARMACEUTICAL CO., INC. (JP) | 1992-12-29 | — | — | US | disclosed |
| EP-0436025-A1 | NOVEL DIBENZ b,e]OXEPIN DERIVATIVES | Hisamitsu Pharmaceutical Co., Inc. (JP) | 1991-07-10 | — | — | EP | disclosed |
| US-4292319-A | MIXTURE WITH AN ANTIULCER AGENT | BOEHRINGER INGELHEIM GMBH (DE) | 1981-09-29 | — | — | US | disclosed |
| US-4256747-A | ANTIINFLAMMATORY AGENTS, PYRIDO/2,3B//1,4/BENZODIAZEPIN-6-ONES | BOEHRINGER INGELHEIM GMBH (DE) | 1981-03-17 | — | — | US | disclosed |
| JP-S55377-A | PREPARATION OF DIBENZOXEPIN DERIVATIVE | DAI ICHI SEIYAKU CO LTD | 1980-01-05 | — | — | JP | disclosed |
| US-4154833-A | INDOMETHACIN (1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOLE-3-ACETIC ACID) WITH PIRENZEPINE (5,11-DIHYDRO-11-((4-METHYL-1-PIPERAZINYL)-ACETYL)-6H-PYRIDO(2,3 -B)(1,4)BENZODIAZEPIN-6-ONE) | BOEHRINGER INGELHEIM GMBH (DE) | 1979-05-15 | — | — | US | disclosed |