Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 2/20 | 0.47 |
| ▸ | PPARD | Q03181 | 2/20 | 0.47 |
| ▸ | PPARA | Q07869 | 2/20 | 0.47 |
| ▸ | CYSLTR2 | Q9NS75 | 15/20 | 0.47 |
| ▸ | CYSLTR1 | Q9Y271 | 15/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | PDE5A | O76074 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9734553 | 0.91 | CYSLTR2 (0.50) | PPARGPPARDPPARACYSLTR2CYSLTR1 | |
| SCHEMBL9734712 | 0.85 | PPARG (0.46) | PPARGPPARDPPARACYSLTR2CYSLTR1 | |
| SCHEMBL9734175 | 0.84 | CYSLTR2 (0.49) | PPARGPPARDPPARACYSLTR2CYSLTR1 | |
| SCHEMBL10893739 | 0.84 | PPARG (0.50) | PPARGPPARDPPARACYSLTR2CYSLTR1 | |
| SCHEMBL9733478 | 0.83 | CYSLTR2 (0.49) | PPARGPPARDPPARACYSLTR2CYSLTR1 | |
| SCHEMBL9733285 | 0.81 | CYSLTR2 (0.59) | PPARGPPARDPPARACYSLTR2CYSLTR1 | |
| Acetic Acid Methyl Ester SCHEMBL11043323 | 0.81 | CYSLTR2 (0.51) | PPARGPPARDPPARACYSLTR2CYSLTR1 | |
| SCHEMBL9733884 | 0.79 | CYSLTR2 (0.47) | PPARGPPARDPPARACYSLTR2CYSLTR1 | |
| SCHEMBL6136976 | 0.78 | PPARG (0.57) | PPARGPPARDPPARACYSLTR2CYSLTR1 | |
| SCHEMBL6138926 | 0.77 | CYSLTR2 (0.49) | PPARGPPARDPPARACYSLTR2CYSLTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5135940-A | Antiallegens, antiinflammatory agents | MERCK FROSST CANADA, INC. (CA) | 1992-08-04 | — | — | US | disclosed |
| EP-0252639-A1 | Leukotriene antagonists | MERCK FROSST CANADA INC. (CA) | 1988-01-13 | — | — | EP | disclosed |
| EP-0104885-B1 | LEUKOTRIENE ANTAGONISTS, THEIR PRODUCTION, AND COMPOSITIONS CONTAINING THEM | MERCK FROSST CANADA INC. (CA) | 1986-06-04 | — | — | EP | disclosed |
| EP-0156233-A2 | Use of leukotriene antagonists for producing cytoprotective pharmaceutical compositions and process for producing cytoprotective pharmaceutical compositions | MERCK & CO. INC. (US) | 1985-10-02 | — | — | EP | disclosed |
| EP-0104885-A1 | Leukotriene antagonists, their production, and compositions containing them | MERCK FROSST CANADA INC. (CA) | 1984-04-04 | — | — | EP | disclosed |