Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | DPP4 | P27487 | 2/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.34 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9733467 | 0.82 | NPC1 (0.33) | CYP2C19ALDH1A1 | |
| SCHEMBL27172650 | 0.77 | CYP1A2 (0.38) | CYP2C19ALDH1A1LMNAKMT2ATSHR | |
| SCHEMBL16894869 | 0.77 | CYP1A2 (0.38) | CYP2C19ALDH1A1LMNAKMT2ATSHR | |
| SCHEMBL15152229 | 0.77 | CYP1A2 (0.38) | CYP2C19ALDH1A1LMNAKMT2ATSHR | |
| SCHEMBL9192107 | 0.76 | DPP4 (0.41) | HPGDDPP4HRH3KMT2AL3MBTL1 | |
| SCHEMBL9733517 | 0.72 | MMP2 (0.35) | KMT2A | |
| SCHEMBL10466402 | 0.69 | DPP4 (0.40) | HPGDALDH1A1DPP4KMT2ADPP8 | |
| SCHEMBL488954 | 0.68 | DPP4 (0.64) | HPGDDPP4L3MBTL1DPP8DPP9 | |
| SCHEMBL1383434 | 0.68 | DPP4 (0.64) | HPGDDPP4L3MBTL1DPP8DPP9 | |
| SCHEMBL488953 | 0.68 | DPP4 (0.64) | HPGDDPP4L3MBTL1DPP8DPP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5114945-A | Spiropiperidine derivatives | GLAXO GROUP LIMITED (GB) | 1992-05-19 | — | — | US | disclosed |
| EP-0330461-A2 | Piperidine derivatives | GLAXO GROUP LIMITED (GB) | 1989-08-30 | — | — | EP | disclosed |