Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 7/20 | 0.81 |
| ▸ | GSK3B | P49841 | 6/20 | 0.81 |
| ▸ | MAOB | P27338 | 2/20 | 0.64 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.64 |
| ▸ | NPC1 | O15118 | 1/20 | 0.63 |
| ▸ | RAB9A | P51151 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.61 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | APP | P05067 | 1/20 | 0.59 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.56 |
| ▸ | PPARG | P37231 | 1/20 | 0.55 |
| ▸ | PPARA | Q07869 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9735217 | 1.00 | BACE1 (0.81) | BACE1GSK3BMAOBABCG2NPC1 | |
| SCHEMBL9344837 | 0.85 | GSK3B (0.76) | BACE1GSK3BMAOBABCG2NPC1 | |
| SCHEMBL9344834 | 0.85 | GSK3B (0.76) | BACE1GSK3BMAOBABCG2NPC1 | |
| SCHEMBL7999153 | 0.85 | GSK3B (0.83) | BACE1GSK3BMAOBABCG2NPC1 | |
| SCHEMBL7999149 | 0.85 | GSK3B (0.83) | BACE1GSK3BMAOBABCG2NPC1 | |
| SCHEMBL527828 | 0.85 | GSK3B (0.80) | BACE1GSK3BMAOBABCG2NPC1 | |
| SCHEMBL527827 | 0.85 | GSK3B (0.80) | BACE1GSK3BMAOBABCG2NPC1 | |
| SCHEMBL8740053 | 0.85 | GSK3B (0.80) | BACE1GSK3BMAOBABCG2NPC1 | |
| Hydrochloric Acid SCHEMBL7054738 | 0.84 | GSK3B (0.78) | BACE1GSK3BMAOBABCG2NPC1 | |
| SCHEMBL6539306 | 0.83 | GSK3B (0.68) | BACE1GSK3BMAOBABCG2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5135955-A | Anticoagulants or antifungal activity | ELI LILLY AND COMPANY (US) | 1992-08-04 | — | — | US | disclosed |
| EP-0339878-A2 | Propanamine derivatives | ELI LILLY AND COMPANY (US) | 1989-11-02 | — | — | EP | disclosed |