SCHEMBL9735470

SCHEMBL9735470

C=C(c1ccccc1Cl)C(O)(Cn1cncn1)c1ccc(Cl)cc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.52
HSP90AA1 P07900 2/20 0.50
CYP3A4 P08684 3/20 0.45
ALDH1A1 P00352 1/20 0.45
KDM4E B2RXH2 2/20 0.37
HTT P42858 2/20 0.37
POLB P06746 1/20 0.37
CYP19A1 P11511 4/20 0.37
PDCD1 Q15116 2/20 0.37
CD274 Q9NZQ7 2/20 0.37
CYP3A5 P20815 1/20 0.35
MEN1 O00255 1/20 0.35
FDPS P14324 1/20 0.35
LMNA P02545 2/20 0.34
CYP2C9 P11712 1/20 0.34
CYP11B1 P15538 1/20 0.34
CYP11B2 P19099 1/20 0.34
CYP2C19 P33261 1/20 0.34
ADRA1A P35348 1/20 0.34
CYP51A1 Q16850 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29594737 0.93 KMT2A (0.46) KMT2AHSP90AA1CYP3A4ALDH1A1POLB
SCHEMBL8675739 0.89 KMT2A (0.56) KMT2AHSP90AA1CYP3A4ALDH1A1KDM4E
SCHEMBL9530413 0.86 HSP90AA1 (0.46) KMT2AHSP90AA1CYP3A4ALDH1A1KDM4E
SCHEMBL9530860 0.86 HSP90AA1 (0.56) KMT2AHSP90AA1CYP3A4ALDH1A1KDM4E
SCHEMBL8674662 0.85 HSP90AA1 (0.41) KMT2AHSP90AA1CYP3A4ALDH1A1POLB
SCHEMBL9531219 0.81 KMT2A (0.51) KMT2AHSP90AA1CYP3A4ALDH1A1KDM4E
SCHEMBL9529992 0.78 CYP3A4 (0.58) KMT2AHSP90AA1CYP3A4CYP19A1CYP3A5
SCHEMBL9867711 0.76 KMT2A (0.49) KMT2AHSP90AA1CYP3A4ALDH1A1KDM4E
Hydrochloric Acid SCHEMBL11139130 0.76 HSP90AA1 (0.81) KMT2AHSP90AA1CYP3A4ALDH1A1KDM4E
SCHEMBL9054399 0.76 HSP90AA1 (0.43) KMT2AHSP90AA1CYP3A4ALDH1A1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4952232-A Antifungal carbinols E. I. DU PONT DE NEMOURS AND COMPANY (US) 1990-08-28 US claimed
US-5084465-A Plant fungicides for agriculture DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1992-01-28 US disclosed
US-4980367-A CONTROLLING PLANT DISEASES E. I. DU PONT DE NEMOURS AND COMPANY (US) 1990-12-25 US disclosed
EP-0390850-A4 ANTIFUNGAL CARBINOLS 1990-12-05 EP disclosed
EP-0390850-A1 ANTIFUNGAL CARBINOLS THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1990-10-10 EP disclosed
US-4952232-A Antifungal carbinols E. I. DU PONT DE NEMOURS AND COMPANY (US) 1990-08-28 US disclosed
WO-1989005581-A1 ANTIFUNGAL CARBINOLS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1989-06-29 WO disclosed