Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.35 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.34 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | CASP1 | P29466 | 1/20 | 0.30 |
| ▸ | BLM | P54132 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9735557 | 1.00 | TMEM97 (0.35) | TMEM97SIGMAR1AVPR1AAPPL3MBTL1 | |
| SCHEMBL9735874 | 0.72 | ALDH1A1 (0.40) | TMEM97SIGMAR1APPALDH1A1NPSR1 | |
| SCHEMBL9736381 | 0.72 | NPSR1 (0.35) | TMEM97SIGMAR1AVPR1AAPPALDH1A1 | |
| SCHEMBL9736590 | 0.72 | NPSR1 (0.35) | TMEM97SIGMAR1AVPR1AAPPALDH1A1 | |
| SCHEMBL10378727 | 0.72 | NPSR1 (0.35) | TMEM97SIGMAR1AVPR1AAPPALDH1A1 | |
| SCHEMBL10378318 | 0.68 | NPSR1 (0.35) | TMEM97SIGMAR1AVPR1AAPPALDH1A1 | |
| SCHEMBL9736469 | 0.68 | NPSR1 (0.35) | TMEM97SIGMAR1AVPR1AAPPALDH1A1 | |
| SCHEMBL10305084 | 0.64 | GAA (0.47) | TMEM97SIGMAR1ALDH1A1NPSR1LMNA | |
| SCHEMBL4860844 | 0.64 | GAA (0.47) | TMEM97SIGMAR1ALDH1A1NPSR1LMNA | |
| SCHEMBL10305099 | 0.64 | GAA (0.47) | TMEM97SIGMAR1ALDH1A1NPSR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5138050-A | 6-amido-1-methyl carbapenems | MERCK & CO., INC. (US) | 1992-08-11 | — | — | US | disclosed |
| WO-1990000170-A1 | NOVEL 6-AMIDO-1-METHYLCARBAPENEMS | MERCK & CO., INC. (US) | 1990-01-11 | — | — | WO | disclosed |
| EP-0350211-A2 | Novel 6-amido-1-methyl carbapenems | MERCK & CO. INC. (US) | 1990-01-10 | — | — | EP | disclosed |