Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 4/20 | 0.60 |
| ▸ | SRD5A1 | P18405 | 2/20 | 0.60 |
| ▸ | STAT3 | P40763 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | CTSV | O60911 | 2/20 | 0.47 |
| ▸ | CTSL | P07711 | 2/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | LIPE | Q05469 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3012026 | 0.88 | SRD5A2 (0.49) | SRD5A2SRD5A1STAT3HTTSMN1; SMN2 | |
| SCHEMBL31498189 | 0.80 | ALOX5 (0.58) | SRD5A2CTSVCTSLKDM4EALDH1A1 | |
| SCHEMBL9265187 | 0.80 | ALOX5 (0.58) | SRD5A2CTSVCTSLKDM4EALDH1A1 | |
| SCHEMBL4886568 | 0.80 | SRD5A2 (0.55) | SRD5A2SRD5A1STAT3HTTSMN1; SMN2 | |
| SCHEMBL5123477 | 0.80 | KDM4E (0.64) | SRD5A2CTSVCTSLKDM4EALDH1A1 | |
| SCHEMBL7174812 | 0.78 | SRD5A2 (0.88) | SRD5A2SRD5A1MAPTKDM4EALDH1A1 | |
| SCHEMBL9735427 | 0.77 | SRD5A2 (0.69) | SRD5A2SRD5A1HTTSMN1; SMN2MAPT | |
| SCHEMBL7054784 | 0.77 | MAPT (0.56) | SRD5A2STAT3HTTSMN1; SMN2MAPT | |
| SCHEMBL31530782 | 0.77 | SRD5A2 (0.64) | SRD5A2MAPTMAPK1TDP1L3MBTL1 | |
| SCHEMBL1013895 | 0.77 | SRD5A2 (0.64) | SRD5A2MAPTMAPK1TDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5126125-A | Decreasing the melanin content in mammalian skin and hair using 5,6-dihydroxindole derivatives | YALE UNIVERSITY (US) | 1992-06-30 | — | — | US | claimed |
| US-5126125-A | Decreasing the melanin content in mammalian skin and hair using 5,6-dihydroxindole derivatives | YALE UNIVERSITY (US) | 1992-06-30 | — | — | US | disclosed |
| US-4956174-A | COSMETICS, TANNING, PIGMENTATION | L'OREAL (FR) | 1990-09-11 | — | — | US | disclosed |