SCHEMBL9736708

SCHEMBL9736708

COc1ccc(CCN(C)CC[C@]2(O)CCc3cc(F)ccc3[C@H]2C(C)C)cc1OC

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 9/20 0.56
CYP2D6 P10635 8/20 0.48
CYP1A2 P05177 2/20 0.47
ALDH1A1 P00352 3/20 0.47
KDM4E B2RXH2 1/20 0.47
PMP22 Q01453 2/20 0.46
BLM P54132 1/20 0.46
MEN1 O00255 4/20 0.44
KMT2A Q03164 4/20 0.44
CACNA1H O95180 4/20 0.42
MAPT P10636 4/20 0.42
CACNA1B Q00975 3/20 0.42
KCNH2 Q12809 2/20 0.42
CACNA1C Q13936 2/20 0.42
ABCB11 O95342 2/20 0.42
NPC1 O15118 1/20 0.42
CACNA1G O43497 1/20 0.42
CACNA1F O60840 1/20 0.42
TP53 P04637 1/20 0.42
CHRM2 P08172 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9827446 1.00 CYP3A4 (0.56) CYP3A4CYP2D6CYP1A2ALDH1A1KDM4E
Hydrochloric Acid SCHEMBL9736375 0.99 CYP3A4 (0.55) CYP3A4CYP2D6CYP1A2ALDH1A1KDM4E
Hydrochloric Acid SCHEMBL9829230 0.99 CYP3A4 (0.55) CYP3A4CYP2D6CYP1A2ALDH1A1KDM4E
SCHEMBL10446897 0.95 CYP3A4 (0.61) CYP3A4CYP2D6CYP1A2ALDH1A1KDM4E
SCHEMBL9736518 0.95 CYP3A4 (0.61) CYP3A4CYP2D6CYP1A2ALDH1A1KDM4E
SCHEMBL9735921 0.94 CYP3A4 (0.58) CYP3A4CYP2D6CYP1A2ALDH1A1KDM4E
SCHEMBL10447243 0.94 CYP3A4 (0.58) CYP3A4CYP2D6CYP1A2ALDH1A1KDM4E
Hydrochloric Acid SCHEMBL10791962 0.90 CYP3A4 (0.55) CYP3A4CYP2D6CYP1A2ALDH1A1PMP22
SCHEMBL9737974 0.90 CYP3A4 (0.57) CYP3A4CYP2D6CYP1A2ALDH1A1PMP22
Hydrochloric Acid SCHEMBL9828647 0.90 CYP3A4 (0.52) CYP3A4CYP2D6CYP1A2ALDH1A1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5120759-A TETRAHYDRONAPHTHALENE DERIVATIVES FOR IMPROVING SHORT-TERM MEMORY HOFFMANN-LA ROCHE INC. (US) 1992-06-09 US disclosed