Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.69 |
| ▸ | NPC1 | O15118 | 2/20 | 0.69 |
| ▸ | MEN1 | O00255 | 1/20 | 0.69 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MMP8 | P22894 | 1/20 | 0.47 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8532867 | 0.93 | KMT2A (0.60) | KMT2ANPC1MEN1POLBNPSR1 | |
| SCHEMBL6014923 | 0.92 | KMT2A (0.75) | KMT2ANPC1MEN1POLBNPSR1 | |
| SCHEMBL3030211 | 0.92 | KMT2A (0.58) | KMT2ANPC1MEN1POLBNPSR1 | |
| SCHEMBL29114074 | 0.92 | KMT2A (0.58) | KMT2ANPC1MEN1POLBNPSR1 | |
| SCHEMBL10830586 | 0.90 | KMT2A (0.73) | KMT2ANPC1MEN1POLBNPSR1 | |
| SCHEMBL8775304 | 0.89 | KMT2A (0.57) | KMT2ANPC1MEN1TDP1TSHR | |
| SCHEMBL1156528 | 0.87 | KMT2A (0.69) | KMT2ANPC1MEN1POLBNPSR1 | |
| SCHEMBL4666968 | 0.87 | MEN1 (0.55) | KMT2ANPC1MEN1TDP1TSHR | |
| SCHEMBL3494511 | 0.87 | KMT2A (0.55) | KMT2ANPC1MEN1TDP1TSHR | |
| SCHEMBL1437086 | 0.86 | KMT2A (0.56) | KMT2ANPC1MEN1POLBNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116947636-A | Preparation method of 2-acyl-4-oxo-butyrate derivative | 华侨大学 | 2023-10-27 | — | — | CN | disclosed |
| US-8673911-B2 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2014-03-18 | — | — | US | disclosed |
| US-8673911-B2 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2014-03-18 | — | — | US | disclosed |
| US-8673911-B2 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2014-03-18 | — | — | US | disclosed |
| US-20140045850-A1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC. (CA) | 2014-02-13 | — | — | US | disclosed |
| US-20140045850-A1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC. (CA) | 2014-02-13 | — | — | US | disclosed |
| US-20140045850-A1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC. (CA) | 2014-02-13 | — | — | US | disclosed |
| US-20110021771-A1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC. (CA) | 2011-01-27 | — | — | US | disclosed |
| US-20110021771-A1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC. (CA) | 2011-01-27 | — | — | US | disclosed |
| US-20110021771-A1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC. (CA) | 2011-01-27 | — | — | US | disclosed |
| EP-2217588-A1 | INHIBITORS OF HISTONE DEACETYLASE | Methylgene, Inc. (CA) | 2010-08-18 | — | — | EP | disclosed |
| WO-2009055917-A1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC. (CA) | 2009-05-07 | — | — | WO | disclosed |
| WO-2009055917-A1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC. (CA) | 2009-05-07 | — | — | WO | disclosed |
| US-6706891-B2 | COMPRISES CONVERSION OF OXALAMIDE TO DITHIOOXALAMIDE, FOLLOWED BY CONVERSION OF THE DITHIOOXALAMIDE TO EITHER A 4,5-BISIMINO-(1,3)DITHIOLANE OR 2,3-BISIMINO-(1,4)DITHIANE | EASTMAN CHEMICAL COMPANY | 2004-03-16 | — | — | US | disclosed |
| EP-1334097-A2 | PROCESS FOR THE PREPARATION OF LIGANDS FOR OLEFIN POLYMERIZATION CATALYSTS | EASTMAN CHEMICAL COMPANY (US) | 2003-08-13 | — | — | EP | disclosed |
| US-20030013894-A1 | Process for the preparation of ligands for olefin polymerization catalysts | E. I. DU PONT DE NEMOURS AND COMPANY | 2003-01-16 | — | — | US | disclosed |
| WO-2002036585-A2 | PROCESS FOR THE PREPARATION OF LIGANDS FOR OLEFIN POLYMERIZATION CATALYSTS | EASTMAN CHEMICAL COMPANY (US) | 2002-05-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110021771-A1 | INHIBITORS OF HISTONE DEACETYLASE | HDAC1, HDAC11, HDAC3 | KMT2A 60/4885NPC1 1513/4885MEN1 3189/4885 |
| US-20030013894-A1 | Process for the preparation of ligands for olefin polymerization catalysts | OCIAD1, OXER1, SULT1E1 | KMT2A 2949/4885NPC1 3663/4885MEN1 1773/4885 |
| US-20140045850-A1 | INHIBITORS OF HISTONE DEACETYLASE | HDAC1, HDAC11, HDAC3 | KMT2A 60/4885NPC1 1513/4885MEN1 3189/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.