Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 2/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
| ▸ | BACE1 | P56817 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9735242 | 0.86 | MAPT (0.33) | SMN1; SMN2 | |
| SCHEMBL9736521 | 0.86 | AXL (0.32) | SMN1; SMN2 | |
| SCHEMBL9735752 | 0.86 | ABCB1 (0.36) | — | |
| SCHEMBL9150597 | 0.86 | TRPV1 (0.34) | PKMHTR2BSMN1; SMN2HIF1ABACE1 | |
| SCHEMBL9735545 | 0.82 | — | — | |
| SCHEMBL9735180 | 0.81 | HTR2B (0.33) | PKMHTR2BSMN1; SMN2HIF1ABACE1 | |
| SCHEMBL7332464 | 0.81 | HTR2B (0.34) | PKMHTR2BSMN1; SMN2HIF1A | |
| SCHEMBL9741124 | 0.79 | HTR2B (0.33) | PKMHTR2BSMN1; SMN2HIF1ABACE1 | |
| SCHEMBL8541429 | 0.79 | MAPT (0.33) | PKMHTR2BSMN1; SMN2HIF1A | |
| SCHEMBL9740513 | 0.79 | HTR2B (0.33) | PKMHTR2BSMN1; SMN2HIF1ABACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5130322-A | CHROMAN DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-07-14 | — | — | US | disclosed |
| EP-0415065-A1 | Chroman derivatives | MERCK PATENT GmbH (DE) | 1991-03-06 | — | — | EP | disclosed |