Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 5/20 | 0.44 |
| ▸ | HTR2A | P28223 | 5/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
| ▸ | MPO | P05164 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10446436 | 0.80 | CYP1A2 (0.47) | TAAR1HTR2A | |
| SCHEMBL9736373 | 0.75 | POLB (0.47) | TAAR1HTR2APOLBATMSLC6A2 | |
| SCHEMBL6600626 | 0.73 | HTR2A (0.48) | HTR2AMPO | |
| SCHEMBL718130 | 0.69 | CYP1A2 (0.47) | TAAR1HTR2A | |
| SCHEMBL31440963 | 0.66 | HTR2A (0.53) | TAAR1HTR2AMPO | |
| SCHEMBL25748455 | 0.66 | HTR2A (0.53) | TAAR1HTR2AMPO | |
| SCHEMBL19304384 | 0.64 | ALDH1A1 (0.39) | TAAR1HTR2AMEP1B | |
| SCHEMBL4835849 | 0.64 | DBH (0.45) | HTR2APOLB | |
| SCHEMBL20630756 | 0.64 | HTR2A (0.73) | TAAR1HTR2APOLBATM | |
| SCHEMBL27828878 | 0.64 | ALDH1A1 (0.34) | CHRM2CHRM1CHRM3MEP1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5120759-A | TETRAHYDRONAPHTHALENE DERIVATIVES FOR IMPROVING SHORT-TERM MEMORY | HOFFMANN-LA ROCHE INC. (US) | 1992-06-09 | — | — | US | disclosed |