Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.46 |
| ▸ | LTB4R2 | Q9NPC1 | 2/20 | 0.43 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.43 |
| ▸ | AGTR1 | P30556 | 10/20 | 0.41 |
| ▸ | AGTR2 | P50052 | 9/20 | 0.41 |
| ▸ | MME | P08473 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6005872 | 0.89 | AGTR1 (0.52) | AGTR1AGTR2 | |
| SCHEMBL9737361 | 0.83 | AGTR1 (0.43) | KMT2AFOLH1LTB4R2LTB4RAGTR1 | |
| SCHEMBL8096066 | 0.80 | TSHR (0.46) | KMT2ALTB4R2AGTR1AGTR2ABCB11 | |
| SCHEMBL6005849 | 0.79 | AGTR1 (0.55) | AGTR1AGTR2PPARG | |
| SCHEMBL6007240 | 0.79 | AGTR1 (0.52) | AGTR1AGTR2PPARG | |
| SCHEMBL8105171 | 0.79 | PPARG (0.48) | LTB4R2SMN1; SMN2PPARG | |
| SCHEMBL6004912 | 0.78 | AGTR1 (0.56) | AGTR1AGTR2 | |
| SCHEMBL6007482 | 0.77 | AGTR1 (0.60) | AGTR1AGTR2PPARG | |
| SCHEMBL6008330 | 0.77 | AGTR1 (0.48) | AGTR1AGTR2 | |
| SCHEMBL6005997 | 0.76 | AGTR1 (0.50) | AGTR1AGTR2MME |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992004335-A2 | RENAL-SELECTIVE BIPHENYLALKYL 1H-SUBSTITUTED-1,2,4-TRIAZOLE ANGIOTENSIN II ANTAGONISTS FOR TREATMENT OF HYPERTENSION | G.D. SEARLE & CO. (US) | 1992-03-19 | — | — | WO | disclosed |