Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 1/20 | 0.44 |
| ▸ | AGTR1 | P30556 | 13/20 | 0.43 |
| ▸ | AGTR2 | P50052 | 13/20 | 0.43 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.39 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9738109 | 1.00 | FOLH1 (0.44) | FOLH1AGTR1AGTR2LTB4RLTB4R2 | |
| SCHEMBL9527548 | 0.94 | FOLH1 (0.41) | FOLH1AGTR1AGTR2LTB4RLTB4R2 | |
| SCHEMBL9738059 | 0.91 | AGTR1 (0.50) | FOLH1AGTR1AGTR2LTB4RLTB4R2 | |
| SCHEMBL9738055 | 0.91 | AGTR1 (0.50) | FOLH1AGTR1AGTR2LTB4RLTB4R2 | |
| SCHEMBL6006616 | 0.89 | AGTR1 (0.55) | AGTR1AGTR2PPARG | |
| SCHEMBL6006614 | 0.89 | AGTR1 (0.55) | AGTR1AGTR2PPARG | |
| SCHEMBL6007236 | 0.83 | AGTR1 (0.52) | AGTR1AGTR2PPARG | |
| SCHEMBL6006201 | 0.83 | AGTR1 (0.55) | AGTR1AGTR2PPARG | |
| SCHEMBL6006203 | 0.83 | AGTR1 (0.55) | AGTR1AGTR2PPARG | |
| SCHEMBL6006901 | 0.82 | AGTR1 (0.65) | AGTR1AGTR2PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992004335-A2 | RENAL-SELECTIVE BIPHENYLALKYL 1H-SUBSTITUTED-1,2,4-TRIAZOLE ANGIOTENSIN II ANTAGONISTS FOR TREATMENT OF HYPERTENSION | G.D. SEARLE & CO. (US) | 1992-03-19 | — | — | WO | disclosed |