Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 3/20 | 0.42 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | DHFR | P00374 | 1/20 | 0.36 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9709512 | 0.92 | AGTR1 (0.42) | DHODHAGTR1PDE4APDE4BPDE4C | |
| SCHEMBL9709777 | 0.91 | AGTR1 (0.43) | AGTR1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9738162 | 0.91 | AGTR1 (0.47) | AGTR1 | |
| SCHEMBL9709530 | 0.87 | AGTR1 (0.43) | AGTR1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9709566 | 0.86 | AGTR1 (0.40) | AGTR1 | |
| SCHEMBL9709744 | 0.85 | AGTR1 (0.47) | AGTR1 | |
| SCHEMBL9709599 | 0.85 | AGTR1 (0.45) | AGTR1 | |
| SCHEMBL9709623 | 0.82 | AGTR1 (0.42) | AGTR1 | |
| SCHEMBL9710152 | 0.81 | AGTR1 (0.38) | DHODHAGTR1 | |
| SCHEMBL9710000 | 0.81 | AGTR1 (0.45) | AGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5157040-A | Treatment of hypertension, ocular hypertension and some CNS disorders | MERCK & CO., INC. (US) | 1992-10-20 | — | — | US | disclosed |