Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 4/20 | 0.55 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.39 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24265408 | 0.78 | IDO1 (0.51) | IDO1SLC6A4FFAR1GPR84LMNA | |
| SCHEMBL9748539 | 0.77 | IDO1 (0.54) | IDO1ADRA2AADRA1AADRA1DADRA1B | |
| SCHEMBL7834166 | 0.76 | IDO1 (0.46) | IDO1ADRA2AADRA1AADRA1DADRA1B | |
| SCHEMBL17319346 | 0.76 | IDO1 (0.64) | IDO1SLC6A4FFAR1GPR84 | |
| SCHEMBL6027055 | 0.75 | SLC9A3 (0.54) | IDO1ADRA2AADRA1AADRA1DADRA1B | |
| SCHEMBL25465495 | 0.75 | IDO1 (0.48) | IDO1ADRA2AADRA1AADRA1DADRA1B | |
| SCHEMBL180403 | 0.75 | IDO1 (0.72) | IDO1ADRA2AADRA1AADRA1DADRA1B | |
| SCHEMBL15330041 | 0.75 | IDO1 (0.72) | IDO1ADRA2AADRA1AADRA1DADRA1B | |
| SCHEMBL17729426 | 0.74 | IDO1 (0.39) | IDO1SLC6A4AVPR1ANOX1HRH3 | |
| SCHEMBL5593655 | 0.74 | MAOA (0.41) | AVPR1AALDH1A1KMT2AHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5132307-A | TETRALIN COMPOUNDS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-07-21 | — | — | US | disclosed |
| EP-0368160-A1 | Tetralin derivatives | MERCK PATENT GmbH (DE) | 1990-05-16 | — | — | EP | disclosed |