Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | PRKDC | P78527 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.44 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.44 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4891360 | 0.90 | MAPT (0.55) | MAPTALDH1A1KDM4ECYP3A4ALOX15 | |
| SCHEMBL1609308 | 0.89 | ALDH1A1 (0.52) | MAPTALDH1A1KDM4ECYP3A4ALOX15 | |
| SCHEMBL16052466 | 0.89 | MAPT (0.60) | MAPTALDH1A1KDM4ECYP3A4ALOX15 | |
| SCHEMBL10542664 | 0.88 | TLR4 (0.47) | MAPTALDH1A1KDM4EHTR1AADRA1D | |
| SCHEMBL10542672 | 0.88 | TLR4 (0.47) | MAPTALDH1A1KDM4EHTR1AADRA1D | |
| SCHEMBL14294326 | 0.88 | MAPT (0.62) | MAPTALDH1A1KDM4ECYP3A4ALOX15 | |
| SCHEMBL10320671 | 0.87 | MAPT (0.68) | MAPTALDH1A1KDM4ECYP3A4ALOX15 | |
| SCHEMBL158285 | 0.87 | MAPT (0.68) | MAPTALDH1A1KDM4ECYP3A4ALOX15 | |
| SCHEMBL24865993 | 0.84 | MAPT (0.60) | MAPTALDH1A1KDM4ECYP3A4ALOX15 | |
| SCHEMBL30867117 | 0.84 | MAPT (0.60) | MAPTALDH1A1KDM4ECYP3A4ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5126125-A | Decreasing the melanin content in mammalian skin and hair using 5,6-dihydroxindole derivatives | YALE UNIVERSITY (US) | 1992-06-30 | — | — | US | disclosed |
| US-4956174-A | COSMETICS, TANNING, PIGMENTATION | L'OREAL (FR) | 1990-09-11 | — | — | US | disclosed |
| US-4822375-A | LIGHTFAST, WEATHER RESISTANT, NATURAL APPEARING HAIR DYES | L'OREAL (FR) | 1989-04-18 | — | — | US | disclosed |