Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC33A1 | O00400 | 4/20 | 0.35 |
| ▸ | PDE5A | O76074 | 1/20 | 0.33 |
| ▸ | PDE1A | P54750 | 1/20 | 0.33 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.33 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.33 |
| ▸ | AGTR1 | P30556 | 3/20 | 0.32 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.31 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.30 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.30 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9739892 | 0.94 | SLC33A1 (0.37) | SLC33A1AGTR1AGTR2 | |
| SCHEMBL9738552 | 0.90 | SLC33A1 (0.34) | SLC33A1AGTR1TRPV1KCNJ6KCNJ5 | |
| SCHEMBL9739948 | 0.89 | SLC33A1 (0.33) | SLC33A1 | |
| SCHEMBL9553055 | 0.89 | SLC33A1 (0.36) | SLC33A1AGTR1AGTR2TRPV1KCNJ6 | |
| SCHEMBL9738288 | 0.88 | SLC33A1 (0.33) | SLC33A1TRPV1KCNJ6KCNJ5KCNJ3 | |
| SCHEMBL9553031 | 0.88 | SLC33A1 (0.36) | SLC33A1AGTR1AGTR2TRPV1KCNJ6 | |
| SCHEMBL9552173 | 0.85 | PDE5A (0.37) | SLC33A1PDE5APDE1APDE1BPDE1C | |
| SCHEMBL9552275 | 0.85 | SLC33A1 (0.34) | SLC33A1AGTR1TRPV1KCNJ6KCNJ5 | |
| SCHEMBL9552812 | 0.84 | SLC33A1 (0.38) | SLC33A1AGTR1AGTR2TRPV1KCNJ6 | |
| SCHEMBL9553593 | 0.84 | SLC33A1 (0.36) | SLC33A1PDE5APDE1APDE1BPDE1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992005161-A1 | 1,3,5-TRISUBSTITUTED-1,2,4-TRIAZOLE COMPOUNDS FOR TREATMENT OF CIRCULATORY DISORDERS | G.D. SEARLE & CO. (US) | 1992-04-02 | — | — | WO | claimed |
| WO-1992005161-A1 | 1,3,5-TRISUBSTITUTED-1,2,4-TRIAZOLE COMPOUNDS FOR TREATMENT OF CIRCULATORY DISORDERS | G.D. SEARLE & CO. (US) | 1992-04-02 | — | — | WO | disclosed |