Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 1/20 | 0.50 |
| ▸ | KIF11 | P52732 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | TDO2 | P48775 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.33 |
| ▸ | WNT3A | P56704 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1243755 | 0.80 | KIF11 (0.46) | AXLKIF11ALDH1A1CA2 | |
| SCHEMBL9740122 | 0.80 | KIF11 (0.31) | AXLKIF11 | |
| SCHEMBL442418 | 0.72 | DAO (0.39) | CES1 | |
| SCHEMBL826095 | 0.69 | AXL (0.52) | AXLKIF11KDM4ESMN1; SMN2HSD17B10 | |
| SCHEMBL30225674 | 0.69 | AXL (0.52) | AXLKIF11KDM4ESMN1; SMN2HSD17B10 | |
| SCHEMBL4276905 | 0.68 | CYP1A2 (0.46) | LMNA | |
| SCHEMBL539330 | 0.68 | CYP1A2 (0.46) | KIF11HSD17B10ALDH1A1HPGDCA2 | |
| SCHEMBL4693055 | 0.68 | — | — | |
| SCHEMBL3071940 | 0.68 | KIF11 (0.42) | AXLKIF11KDM4ESMN1; SMN2HSD17B10 | |
| SCHEMBL12683720 | 0.67 | AXL (1.00) | AXLKIF11IDO1TRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5175157-A | Cardiovascular disorders | BOEHRINGER INGELHEIM GMBH (DE) | 1992-12-29 | — | — | US | disclosed |