Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | GAA | P10253 | 4/20 | 0.58 |
| ▸ | LMNA | P02545 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | GFER | P55789 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | TUBB4A | P04350 | 3/20 | 0.57 |
| ▸ | TUBB | P07437 | 3/20 | 0.57 |
| ▸ | TUBA3C | P0DPH7 | 3/20 | 0.57 |
| ▸ | TUBA1B | P68363 | 3/20 | 0.57 |
| ▸ | TUBA4A | P68366 | 3/20 | 0.57 |
| ▸ | TUBB4B | P68371 | 3/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9739684 | 0.91 | MAPT (0.56) | MAPTGAALMNAALDH1A1HTT | |
| SCHEMBL9740073 | 0.80 | TUBB4A (0.51) | GAAALDH1A1TUBB4ATUBBTUBA3C | |
| SCHEMBL9741596 | 0.80 | TUBB1 (0.56) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL9740472 | 0.78 | GAA (0.59) | MAPTGAALMNAALDH1A1HTT | |
| SCHEMBL9740914 | 0.74 | TUBB1 (0.56) | ALDH1A1KDM4ETUBB4ATUBBTUBA3C | |
| SCHEMBL9740244 | 0.74 | MAPT (0.58) | MAPTGAALMNAALDH1A1HTT | |
| SCHEMBL9740728 | 0.74 | MAPT (0.36) | MAPTGAALMNAALDH1A1HTT | |
| SCHEMBL2343438 | 0.74 | MAPT (1.00) | MAPTGAALMNAALDH1A1HTT | |
| SCHEMBL9187840 | 0.73 | TUBB4A (1.00) | MAPTGAALMNAALDH1A1HTT | |
| SCHEMBL9185804 | 0.73 | TUBB4A (0.77) | MAPTGAALMNAALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5175157-A | Cardiovascular disorders | BOEHRINGER INGELHEIM GMBH (DE) | 1992-12-29 | — | — | US | disclosed |