Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 1/20 | 0.41 |
| ▸ | HMGCR | P04035 | 2/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | METAP2 | P50579 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.34 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.34 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | XBP1 | P17861 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10455677 | 0.75 | CYSLTR2 (0.37) | HMGCRALOX5MAPTTUBB1LMNA | |
| SCHEMBL9741003 | 0.73 | PRKCI (0.49) | PRKCIHMGCRALOX5CA12PPARA | |
| SCHEMBL9739756 | 0.72 | PRKCI (0.56) | PRKCIHMGCRALOX5CA12PTPN1 | |
| SCHEMBL5587709 | 0.72 | PTPN1 (0.51) | PRKCIHMGCRALOX5PPARGPPARA | |
| SCHEMBL31456069 | 0.71 | CYP1A2 (0.50) | HMGCRALOX5 | |
| SCHEMBL7096047 | 0.70 | HMGCR (0.49) | HMGCRALOX5CA12PPARGPPARA | |
| SCHEMBL9742195 | 0.69 | PRKCI (0.39) | PRKCIHMGCRPPARGPPARA | |
| SCHEMBL10502725 | 0.69 | PRKCI (0.42) | PRKCIHMGCRPPARGPPARA | |
| SCHEMBL8473100 | 0.69 | HMGCR (0.44) | HMGCRALOX5PPARGPPARAMAPT | |
| SCHEMBL9525677 | 0.69 | NCOA1 (0.44) | HMGCRALOX5PPARGPPARAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5087638-A | Inhibitors of mammalian leukotriene biosynthesis | MERCK FROSST CANADA, INC. (CA) | 1992-02-11 | — | — | US | disclosed |
| EP-0338782-A1 | Benzofuran derivatives | MERCK FROSST CANADA INC. (CA) | 1989-10-25 | — | — | EP | disclosed |
| US-4863958-A | TREATING ALLERGIC CONDITIONS, ASTHMA, CARDIOVASCULAR DISORDERS, AND INFLAMMATION | MERCK FROSST CANADA, INC. (CA) | 1989-09-05 | — | — | US | disclosed |
| EP-0165810-B1 | BENZOFURAN AND BENZOTHIOPHENE DERIVATIVES, THEIR USE IN INHIBITING MAMMALIAN LEUKOTRIENE BIOSYNTHESIS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE DERIVATIVES | MERCK FROSST CANADA INC. (CA) | 1989-08-23 | — | — | EP | disclosed |
| EP-0200443-B1 | LIPOXYGENASE INHIBITORS | MERCK FROSST CANADA INC. (CA) | 1989-03-01 | — | — | EP | disclosed |
| US-4663347-A | ANTIINFLAMMATORY, ANTIALLERGENS, CARDIOVASCULAR | MERCK FROSST CANADA, INC. (CA) | 1987-05-05 | — | — | US | disclosed |
| EP-0200443-A1 | Lipoxygenase inhibitors | MERCK FROSST CANADA INC. (CA) | 1986-11-05 | — | — | EP | disclosed |
| EP-0165810-A2 | Benzofuran and benzothiophene derivatives, their use in inhibiting mammalian leukotriene biosynthesis, and pharmaceutical compositions containing these derivatives | MERCK FROSST CANADA INC. (CA) | 1985-12-27 | — | — | EP | disclosed |