Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 18/20 | 0.87 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.80 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9740324 | 0.93 | ALOX5 (1.00) | ALOX5ALOX15 | |
| SCHEMBL9740417 | 0.91 | ALOX5 (0.83) | ALOX5ALOX15 | |
| SCHEMBL9740342 | 0.91 | ALOX5 (1.00) | ALOX5ALOX15 | |
| SCHEMBL6009815 | 0.89 | ALOX5 (1.00) | ALOX5ALOX15 | |
| SCHEMBL30095994 | 0.89 | ALOX5 (1.00) | ALOX5ALOX15 | |
| SCHEMBL10603436 | 0.88 | ALOX5 (0.78) | ALOX5ALOX15 | |
| SCHEMBL9739591 | 0.83 | ALOX5 (1.00) | ALOX5ALOX15 | |
| SCHEMBL9742551 | 0.83 | ALOX5 (0.61) | ALOX5ALOX15 | |
| SCHEMBL9742547 | 0.80 | ALOX5 (0.77) | ALOX5ALOX15 | |
| SCHEMBL9741972 | 0.80 | ALOX5 (0.84) | ALOX5ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5087638-A | Inhibitors of mammalian leukotriene biosynthesis | MERCK FROSST CANADA, INC. (CA) | 1992-02-11 | — | — | US | disclosed |
| EP-0338782-A1 | Benzofuran derivatives | MERCK FROSST CANADA INC. (CA) | 1989-10-25 | — | — | EP | disclosed |
| US-4863958-A | TREATING ALLERGIC CONDITIONS, ASTHMA, CARDIOVASCULAR DISORDERS, AND INFLAMMATION | MERCK FROSST CANADA, INC. (CA) | 1989-09-05 | — | — | US | disclosed |
| EP-0165810-B1 | BENZOFURAN AND BENZOTHIOPHENE DERIVATIVES, THEIR USE IN INHIBITING MAMMALIAN LEUKOTRIENE BIOSYNTHESIS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE DERIVATIVES | MERCK FROSST CANADA INC. (CA) | 1989-08-23 | — | — | EP | disclosed |
| EP-0165810-A2 | Benzofuran and benzothiophene derivatives, their use in inhibiting mammalian leukotriene biosynthesis, and pharmaceutical compositions containing these derivatives | MERCK FROSST CANADA INC. (CA) | 1985-12-27 | — | — | EP | disclosed |