Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.42 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.40 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2300723 | 0.72 | IMPDH2 (0.52) | MAP2K1IMPDH2IMPDH1MCL1DYRK1A | |
| SCHEMBL7278872 | 0.69 | MCL1 (0.37) | MAP2K1IMPDH2IMPDH1MCL1DYRK1A | |
| SCHEMBL27479367 | 0.68 | HTR2C (0.34) | SLC6A4 | |
| SCHEMBL6009041 | 0.64 | MAP2K1 (0.53) | MAP2K1IMPDH2IMPDH1MCL1DYRK1A | |
| SCHEMBL403956 | 0.64 | IMPDH2 (0.57) | MAP2K1IMPDH2IMPDH1MCL1DYRK1A | |
| SCHEMBL30309353 | 0.64 | IMPDH2 (0.57) | MAP2K1IMPDH2IMPDH1MCL1DYRK1A | |
| SCHEMBL645878 | 0.64 | CA1 (0.41) | MAP2K1MCL1TSHRKDM4EALDH1A1 | |
| SCHEMBL9739950 | 0.63 | IMPDH2 (0.41) | MAP2K1IMPDH2IMPDH1MCL1DYRK1A | |
| SCHEMBL7299420 | 0.63 | CA1 (0.40) | IMPDH2IMPDH1DYRK1ATSHRKDM4E | |
| SCHEMBL10254 | 0.61 | PARP1 (0.50) | MAP2K1IMPDH2IMPDH1MCL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5175157-A | Cardiovascular disorders | BOEHRINGER INGELHEIM GMBH (DE) | 1992-12-29 | — | — | US | disclosed |