Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2B | Q02880 | 5/20 | 0.88 |
| ▸ | TOP2A | P11388 | 4/20 | 0.88 |
| ▸ | KDM1A | O60341 | 3/20 | 0.88 |
| ▸ | GLA | P06280 | 2/20 | 0.88 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.88 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.88 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.88 |
| ▸ | CASP1 | P29466 | 2/20 | 0.88 |
| ▸ | CASP7 | P55210 | 2/20 | 0.88 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.88 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.88 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.88 |
| ▸ | TP53 | P04637 | 1/20 | 0.88 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.88 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.88 |
| ▸ | TOP1 | P11387 | 1/20 | 0.88 |
| ▸ | DRD2 | P14416 | 1/20 | 0.88 |
| ▸ | TSHR | P16473 | 1/20 | 0.88 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.88 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.88 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Amsacrine SCHEMBL29350869 | 0.94 | TOP2B (1.00) | TOP2BTOP2AKDM1AGLACYP1A2 | |
| Amsacrine SCHEMBL6256280 | 0.94 | TOP2B (1.00) | TOP2BTOP2AKDM1AGLACYP1A2 | |
| Amsacrine SCHEMBL28336991 | 0.94 | TOP2B (1.00) | TOP2BTOP2AKDM1AGLACYP1A2 | |
| Amsacrine SCHEMBL29360354 | 0.94 | TOP2B (1.00) | TOP2BTOP2AKDM1AGLACYP1A2 | |
| Amsacrine SCHEMBL4047 | 0.94 | TOP2B (1.00) | TOP2BTOP2AKDM1AGLACYP1A2 | |
| Amsacrine SCHEMBL1320825 | 0.92 | KMT2A (1.00) | TOP2BTOP2AKDM1AGLACYP1A2 | |
| Amsacrine SCHEMBL31316257 | 0.92 | KMT2A (1.00) | TOP2BTOP2AKDM1AGLACYP1A2 | |
| Amsacrine SCHEMBL31237896 | 0.91 | TOP2B (0.95) | TOP2BTOP2AKDM1AGLACYP1A2 | |
| Amsacrine SCHEMBL2920983 | 0.91 | TOP2B (0.95) | TOP2BTOP2AKDM1AGLACYP1A2 | |
| Amsacrine SCHEMBL21827756 | 0.88 | TOP2B (0.89) | TOP2BTOP2AKDM1AGLACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5128345-A | CARCINOSTATIC COMPOSITION COMPRISING INDOLQUINOLINES | MECT CORPORATION (JP) | 1992-07-07 | — | — | US | disclosed |
| EP-0332190-A2 | Condensed quinoline system compound, condensed acridine system compound, process for preparing the same, and carcinostatic composition containing the same | MECT CORPORATION (JP) | 1989-09-13 | — | — | EP | disclosed |