Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.44 |
| ▸ | SSTR1 | P30872 | 6/20 | 0.38 |
| ▸ | SSTR3 | P32745 | 6/20 | 0.38 |
| ▸ | KCNJ1 | P48048 | 5/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.37 |
| ▸ | MGAM | O43451 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9739389 | 0.99 | HRH3 (0.43) | HRH3SSTR1SSTR3KCNJ1KCNH2 | |
| SCHEMBL9739293 | 0.88 | ABCG2 (0.46) | HRH3KCNJ1KCNH2ALDH1A1MEN1 | |
| SCHEMBL9740102 | 0.88 | KCNH2 (0.41) | HRH3SSTR3KCNH2ALDH1A1SIGMAR1 | |
| Hydrochloric Acid SCHEMBL9740815 | 0.87 | ABCG2 (0.46) | HRH3KCNJ1KCNH2ALDH1A1MEN1 | |
| SCHEMBL9739283 | 0.87 | HRH3 (0.41) | HRH3ALDH1A1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL9739083 | 0.86 | HRH3 (0.40) | HRH3ALDH1A1MEN1KMT2A | |
| SCHEMBL9739319 | 0.76 | SMN1; SMN2 (0.42) | HRH3ALDH1A1 | |
| Hydrochloric Acid SCHEMBL9740153 | 0.76 | ABCB1 (0.45) | HRH3ALDH1A1KMT2A | |
| SCHEMBL9739180 | 0.76 | SMN1; SMN2 (0.43) | ALDH1A1 | |
| Hydrochloric Acid SCHEMBL9739564 | 0.76 | CYP3A4 (0.41) | HRH3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5175157-A | Cardiovascular disorders | BOEHRINGER INGELHEIM GMBH (DE) | 1992-12-29 | — | — | US | disclosed |
| EP-0224794-B1 | CYCLIC AMINE DERIVATIVES, MEDICINES CONTAINING THESE COMPOUNDS AND PROCESS FOR THEIR PREPARATION | Dr. Karl Thomae GmbH (DE) | 1990-09-12 | — | — | EP | disclosed |
| EP-0224794-A2 | Cyclic amine derivatives, medicines containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1987-06-10 | — | — | EP | disclosed |