Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.60 |
| ▸ | LMNA | P02545 | 3/20 | 0.60 |
| ▸ | MAPT | P10636 | 7/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.60 |
| ▸ | NPC1 | O15118 | 3/20 | 0.60 |
| ▸ | RAB9A | P51151 | 2/20 | 0.60 |
| ▸ | LY96 | Q9Y6Y9 | 2/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.60 |
| ▸ | PKM | P14618 | 1/20 | 0.60 |
| ▸ | XBP1 | P17861 | 1/20 | 0.60 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.60 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 4/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | MAOB | P27338 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9740370 | 1.00 | ATM (0.61) | ATMKDM4ESMN1; SMN2LMNAMAPT | |
| SCHEMBL9123520 | 0.87 | MAPT (0.61) | ATMKDM4ESMN1; SMN2LMNAMAPT | |
| SCHEMBL10335357 | 0.84 | MAPT (0.61) | ATMKDM4ESMN1; SMN2LMNAMAPT | |
| SCHEMBL9048733 | 0.75 | CA12 (0.41) | KDM4ESMN1; SMN2MAPTALDH1A1NPC1 | |
| SCHEMBL9048726 | 0.75 | CA12 (0.41) | KDM4ESMN1; SMN2MAPTALDH1A1NPC1 | |
| SCHEMBL9049778 | 0.75 | DYRK1A (0.59) | KDM4ESMN1; SMN2LMNAMAPTALDH1A1 | |
| SCHEMBL11610072 | 0.75 | MAPT (1.00) | ATMKDM4ESMN1; SMN2LMNAMAPT | |
| SCHEMBL10062876 | 0.75 | MAPT (1.00) | ATMKDM4ESMN1; SMN2LMNAMAPT | |
| SCHEMBL9049784 | 0.75 | DYRK1A (0.59) | KDM4ESMN1; SMN2LMNAMAPTALDH1A1 | |
| SCHEMBL11610067 | 0.75 | MAPT (1.00) | ATMKDM4ESMN1; SMN2LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5104869-A | Renin inhibitors | AMERICAN CYANAMID COMPANY (US) | 1992-04-14 | — | — | US | disclosed |
| EP-0427939-A2 | Renin inhibitors | AMERICAN CYANAMID COMPANY (US) | 1991-05-22 | — | — | EP | disclosed |