Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | HCN4 | Q9Y3Q4 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | DHCR7 | Q9UBM7 | 1/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.40 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9739427 | 0.90 | HCN4 (0.52) | MAPTHCN4CYP3A4ALOX15DHCR7 | |
| Cilobradine SCHEMBL30169956 | 0.90 | HCN4 (0.57) | MAPTHCN4CYP3A4ALOX15DHCR7 | |
| Cilobradine SCHEMBL1855245 | 0.90 | HCN4 (0.57) | MAPTHCN4CYP3A4ALOX15DHCR7 | |
| Cilobradine SCHEMBL628133 | 0.90 | HCN4 (0.57) | MAPTHCN4CYP3A4ALOX15DHCR7 | |
| SCHEMBL9740036 | 0.89 | MAPT (0.49) | MAPTHCN4CYP3A4ALOX15DHCR7 | |
| Cilobradine SCHEMBL9518220 | 0.89 | CYP3A4 (0.58) | MAPTHCN4CYP3A4ALOX15DHCR7 | |
| Cilobradine SCHEMBL2459609 | 0.89 | CYP3A4 (0.58) | MAPTHCN4CYP3A4ALOX15DHCR7 | |
| Cilobradine SCHEMBL29896706 | 0.89 | CYP3A4 (0.58) | MAPTHCN4CYP3A4ALOX15DHCR7 | |
| Cilobradine SCHEMBL9740702 | 0.89 | HCN4 (0.56) | MAPTHCN4CYP3A4ALOX15DHCR7 | |
| SCHEMBL9739292 | 0.87 | HCN4 (0.51) | MAPTHCN4CYP3A4ALOX15DHCR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5175157-A | Cardiovascular disorders | BOEHRINGER INGELHEIM GMBH (DE) | 1992-12-29 | — | — | US | disclosed |
| EP-0224794-B1 | CYCLIC AMINE DERIVATIVES, MEDICINES CONTAINING THESE COMPOUNDS AND PROCESS FOR THEIR PREPARATION | Dr. Karl Thomae GmbH (DE) | 1990-09-12 | — | — | EP | disclosed |
| EP-0224794-A2 | Cyclic amine derivatives, medicines containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1987-06-10 | — | — | EP | disclosed |