Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Cilobradine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.42 |
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.42 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.42 |
| ▸ | SIGMAR1 known ✓ | Q99720 | 1/20 | 0.41 |
| ▸ | HCN4 | Q9Y3Q4 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | DHCR7 | Q9UBM7 | 1/20 | 0.47 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cilobradine SCHEMBL30169956 | 0.99 | HCN4 (0.57) | HCN4MAPTCYP3A4ALOX15DHCR7 | |
| Cilobradine SCHEMBL628133 | 0.99 | HCN4 (0.57) | HCN4MAPTCYP3A4ALOX15DHCR7 | |
| Cilobradine SCHEMBL1855245 | 0.99 | HCN4 (0.57) | HCN4MAPTCYP3A4ALOX15DHCR7 | |
| Cilobradine SCHEMBL9518220 | 0.98 | CYP3A4 (0.58) | HCN4MAPTCYP3A4ALOX15DHCR7 | |
| Cilobradine SCHEMBL2459609 | 0.98 | CYP3A4 (0.58) | HCN4MAPTCYP3A4ALOX15DHCR7 | |
| Cilobradine SCHEMBL29896706 | 0.98 | CYP3A4 (0.58) | HCN4MAPTCYP3A4ALOX15DHCR7 | |
| Hydrochloric Acid SCHEMBL9739678 | 0.95 | CYP3A4 (0.57) | HCN4MAPTCYP3A4ALOX15DHCR7 | |
| SCHEMBL9740314 | 0.95 | HCN4 (0.53) | HCN4MAPTCYP3A4ALOX15DHCR7 | |
| SCHEMBL9739258 | 0.94 | DHCR7 (0.57) | HCN4MAPTCYP3A4ALOX15DHCR7 | |
| SCHEMBL9742193 | 0.94 | HCN4 (0.52) | HCN4MAPTCYP3A4ALOX15DHCR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5175157-A | Cardiovascular disorders | BOEHRINGER INGELHEIM GMBH (DE) | 1992-12-29 | — | — | US | disclosed |
| EP-0224794-B1 | CYCLIC AMINE DERIVATIVES, MEDICINES CONTAINING THESE COMPOUNDS AND PROCESS FOR THEIR PREPARATION | Dr. Karl Thomae GmbH (DE) | 1990-09-12 | — | — | EP | disclosed |