Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 6/20 | 1.00 |
| ▸ | GPR17 | Q13304 | 3/20 | 0.56 |
| ▸ | FBP1 | P09467 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9731831 | 0.89 | GRIN1 (0.80) | GRIN1GPR17FBP1MEN1MAPT | |
| SCHEMBL9739526 | 0.87 | GRIN1 (0.77) | GRIN1GPR17FBP1KDM4EMEN1 | |
| SCHEMBL9732371 | 0.81 | GRIN1 (0.67) | GRIN1GPR17FBP1KDM4EMEN1 | |
| SCHEMBL9731281 | 0.81 | GRIN1 (0.67) | GRIN1GPR17FBP1MEN1MAPT | |
| SCHEMBL9731514 | 0.80 | GRIN1 (0.68) | GRIN1GPR17FBP1 | |
| SCHEMBL9730824 | 0.78 | GRIN1 (0.64) | GRIN1GPR17FBP1KDM4EMEN1 | |
| SCHEMBL9731315 | 0.76 | GRIN1 (0.61) | GRIN1GPR17MEN1ALDH1A1MAPT | |
| SCHEMBL9732016 | 0.76 | GRIN1 (0.60) | GRIN1GPR17FBP1ALDH1A1MAPT | |
| SCHEMBL266498 | 0.74 | GPR17 (0.70) | GRIN1GPR17FBP1MEN1HPGD | |
| SCHEMBL9340971 | 0.74 | GPR17 (0.71) | GRIN1GPR17KDM4EMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992020649-A2 | SUBSTITUTED 2-CARBOXYINDOLES HAVING PHARMACEUTICAL ACTIVITY | WARNER-LAMBERT COMPANY (US) | 1992-11-26 | — | — | WO | claimed |
| WO-1992020649-A2 | SUBSTITUTED 2-CARBOXYINDOLES HAVING PHARMACEUTICAL ACTIVITY | WARNER-LAMBERT COMPANY (US) | 1992-11-26 | — | — | WO | disclosed |