Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 4/20 | 0.64 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | GPR17 | Q13304 | 2/20 | 0.47 |
| ▸ | FBP1 | P09467 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | FPR2 | P25090 | 1/20 | 0.45 |
| ▸ | MARS1 | P56192 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9731504 | 0.92 | GRIN1 (0.53) | GRIN1MEN1KMT2AMAPTNPC1 | |
| SCHEMBL9731831 | 0.89 | GRIN1 (0.80) | GRIN1MEN1KMT2AMAPTNPC1 | |
| SCHEMBL9731682 | 0.88 | GRIN1 (0.54) | GRIN1GPR17FBP1CNR1 | |
| SCHEMBL9739526 | 0.83 | GRIN1 (0.77) | GRIN1MEN1KMT2AGPR17FBP1 | |
| SCHEMBL9731281 | 0.82 | GRIN1 (0.67) | GRIN1MEN1KMT2AMAPTNPC1 | |
| SCHEMBL9732016 | 0.79 | GRIN1 (0.60) | GRIN1KMT2AMAPTGPR17FBP1 | |
| SCHEMBL9740602 | 0.78 | GRIN1 (1.00) | GRIN1MEN1KMT2AMAPTGPR17 | |
| SCHEMBL9731514 | 0.77 | GRIN1 (0.68) | GRIN1GPR17FBP1 | |
| SCHEMBL9740348 | 0.73 | GRIN1 (0.81) | GRIN1GPR17FBP1 | |
| SCHEMBL9341649 | 0.73 | GRIN1 (0.47) | GRIN1MEN1KMT2AMAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992020649-A2 | SUBSTITUTED 2-CARBOXYINDOLES HAVING PHARMACEUTICAL ACTIVITY | WARNER-LAMBERT COMPANY (US) | 1992-11-26 | — | — | WO | claimed |
| WO-1992020649-A2 | SUBSTITUTED 2-CARBOXYINDOLES HAVING PHARMACEUTICAL ACTIVITY | WARNER-LAMBERT COMPANY (US) | 1992-11-26 | — | — | WO | disclosed |
| US-5145845-A | Substituted 2-carboxylindoles having pharmaceutical activity | WARNER-LAMBERT CO. (US) | 1992-09-08 | — | — | US | disclosed |