Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7702136 | 0.83 | JAK3 (0.37) | JAK3 | |
| SCHEMBL30901847 | 0.78 | SMN1; SMN2 (0.40) | JAK3GRM5 | |
| SCHEMBL3504558 | 0.78 | SMN1; SMN2 (0.40) | JAK3GRM5 | |
| SCHEMBL9738439 | 0.78 | JAK3 (0.31) | JAK3 | |
| SCHEMBL13506002 | 0.76 | GRM5 (0.38) | JAK3GRM5 | |
| SCHEMBL31676354 | 0.75 | NPC1 (0.34) | — | |
| SCHEMBL21316764 | 0.75 | — | — | |
| SCHEMBL2408636 | 0.74 | KDM4E (0.40) | JAK3GRM5 | |
| SCHEMBL9738264 | 0.70 | — | — | |
| SCHEMBL8012352 | 0.69 | GRM5 (0.35) | JAK3GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11891364-B2 | Methods of selectively forming substituted pyrazines | R.J. REYNOLDS TOBACCO COMPANY (US) | 2024-02-06 | — | — | US | claimed |
| CN-117486811-A | Method for selectively forming substituted pyrazines | R.J.雷诺兹烟草公司 | 2024-02-02 | — | — | CN | claimed |
| CN-110637012-B | Method for selectively forming substituted pyrazines | R.J.雷诺兹烟草公司 | 2023-11-24 | — | — | CN | claimed |
| US-20210403437-A1 | METHODS OF SELECTIVELY FORMING SUBSTITUTED PYRAZINES | REYNOLDS TOBACCO CO R (US) | 2021-12-30 | — | — | US | claimed |
| US-11091446-B2 | Methods of selectively forming substituted pyrazines | R.J. REYNOLDS TOBACCO COMPANY (US) | 2021-08-17 | — | — | US | claimed |
| EP-3601238-A1 | METHODS OF SELECTIVELY FORMING SUBSTITUTED PYRAZINES | R. J. Reynolds Tobacco Company (US) | 2020-02-05 | — | — | EP | claimed |
| CN-110637012-A | Process for selectively forming substituted pyrazines | R.J.雷诺兹烟草公司 | 2019-12-31 | — | — | CN | claimed |
| WO-2018172995-A1 | METHODS OF SELECTIVELY FORMING SUBSTITUTED PYRAZINES | R. J. REYNOLDS TOBACCO COMPANY (US) | 2018-09-27 | — | — | WO | claimed |
| US-20180273492-A1 | METHODS OF SELECTIVELY FORMING SUBSTITUTED PYRAZINES | R.J. REYNOLDS TOBACCO COMPANY | 2018-09-27 | — | — | US | claimed |
| US-11891364-B2 | Methods of selectively forming substituted pyrazines | R.J. REYNOLDS TOBACCO COMPANY (US) | 2024-02-06 | — | — | US | disclosed |
| CN-117486811-A | Method for selectively forming substituted pyrazines | R.J.雷诺兹烟草公司 | 2024-02-02 | — | — | CN | disclosed |
| CN-110637012-B | Method for selectively forming substituted pyrazines | R.J.雷诺兹烟草公司 | 2023-11-24 | — | — | CN | disclosed |
| US-20210403437-A1 | METHODS OF SELECTIVELY FORMING SUBSTITUTED PYRAZINES | REYNOLDS TOBACCO CO R (US) | 2021-12-30 | — | — | US | disclosed |
| US-11091446-B2 | Methods of selectively forming substituted pyrazines | R.J. REYNOLDS TOBACCO COMPANY (US) | 2021-08-17 | — | — | US | disclosed |
| EP-3601238-A1 | METHODS OF SELECTIVELY FORMING SUBSTITUTED PYRAZINES | R. J. Reynolds Tobacco Company (US) | 2020-02-05 | — | — | EP | disclosed |
| CN-110637012-A | Process for selectively forming substituted pyrazines | R.J.雷诺兹烟草公司 | 2019-12-31 | — | — | CN | disclosed |
| WO-2018172995-A1 | METHODS OF SELECTIVELY FORMING SUBSTITUTED PYRAZINES | R. J. REYNOLDS TOBACCO COMPANY (US) | 2018-09-27 | — | — | WO | disclosed |
| US-20180273492-A1 | METHODS OF SELECTIVELY FORMING SUBSTITUTED PYRAZINES | R.J. REYNOLDS TOBACCO COMPANY | 2018-09-27 | — | — | US | disclosed |
| US-5172706-A | Smoking compositions containing an oxalate flavorant-release additive | PHILIP MORRIS INCORPORATED (US) | 1992-12-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180273492-A1 | METHODS OF SELECTIVELY FORMING SUBSTITUTED PYRAZINES | KHK, HK2, HK1 | JAK3 1934/4885GRM5 931/4885 |
| US-11891364-B2 | Methods of selectively forming substituted pyrazines | KHK, HK2, HK1 | JAK3 1934/4885GRM5 931/4885 |
| US-11091446-B2 | Methods of selectively forming substituted pyrazines | KHK, HK2, HK1 | JAK3 1934/4885GRM5 931/4885 |
| US-20210403437-A1 | METHODS OF SELECTIVELY FORMING SUBSTITUTED PYRAZINES | KHK, HK2, HK1 | JAK3 1934/4885GRM5 931/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.