Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEK | Q02763 | 13/20 | 0.62 |
| ▸ | KDR | P35968 | 9/20 | 0.59 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.58 |
| ▸ | AURKB | Q96GD4 | 11/20 | 0.51 |
| ▸ | AURKA | O14965 | 8/20 | 0.51 |
| ▸ | LCK | P06239 | 5/20 | 0.51 |
| ▸ | TPX2 | Q9ULW0 | 4/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
| ▸ | KIT | P10721 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL973160 | 0.92 | TEK (0.73) | TEKKDRPDE10AAURKBAURKA | |
| SCHEMBL974952 | 0.91 | TEK (0.62) | TEKKDRPDE10AAURKBAURKA | |
| SCHEMBL974173 | 0.88 | PDE10A (0.72) | TEKKDRPDE10AAURKBAURKA | |
| SCHEMBL974060 | 0.84 | TEK (0.82) | TEKKDRAURKBAURKALCK | |
| SCHEMBL972867 | 0.83 | TEK (0.77) | TEKKDRAURKBAURKALCK | |
| SCHEMBL974111 | 0.82 | TEK (0.63) | TEKKDRPDE10AAURKBAURKA | |
| SCHEMBL973068 | 0.80 | TEK (0.70) | TEKKDRPDE10AAURKBAURKA | |
| SCHEMBL973155 | 0.80 | TEK (0.81) | TEKKDRAURKBAURKALCK | |
| SCHEMBL973142 | 0.80 | TEK (0.80) | TEKKDRAURKBAURKALCK | |
| SCHEMBL974106 | 0.79 | TEK (0.81) | TEKKDRAURKBAURKALCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7868177-B2 | Multi-cyclic compounds and method of use | AMGEN INC. (US) | 2011-01-11 | — | — | US | claimed |
| EP-1994030-B1 | MULTI-CYCLIC COMPOUNDS AND METHOD OF USE | AMGEN INC (US) | 2010-08-25 | — | — | EP | claimed |
| EP-1994030-B1 | MULTI-CYCLIC COMPOUNDS AND METHOD OF USE | AMGEN INC (US) | 2010-08-25 | — | — | EP | disclosed |