Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.72 |
| ▸ | TEK | Q02763 | 10/20 | 0.71 |
| ▸ | AURKB | Q96GD4 | 12/20 | 0.55 |
| ▸ | AURKA | O14965 | 8/20 | 0.55 |
| ▸ | TPX2 | Q9ULW0 | 4/20 | 0.55 |
| ▸ | KDR | P35968 | 6/20 | 0.54 |
| ▸ | LCK | P06239 | 4/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL973068 | 0.91 | TEK (0.70) | PDE10ATEKAURKBAURKATPX2 | |
| SCHEMBL973160 | 0.89 | TEK (0.73) | PDE10ATEKAURKBAURKATPX2 | |
| SCHEMBL974111 | 0.89 | TEK (0.63) | PDE10ATEKAURKBAURKATPX2 | |
| SCHEMBL973999 | 0.88 | PDE10A (0.67) | PDE10ATEKAURKBAURKATPX2 | |
| SCHEMBL974146 | 0.88 | TEK (0.62) | PDE10ATEKAURKBAURKATPX2 | |
| SCHEMBL974952 | 0.88 | TEK (0.62) | PDE10ATEKAURKBAURKATPX2 | |
| SCHEMBL974172 | 0.87 | TEK (0.70) | PDE10ATEKAURKBAURKATPX2 | |
| SCHEMBL972047 | 0.87 | TEK (0.72) | PDE10ATEKAURKBAURKATPX2 | |
| SCHEMBL973539 | 0.86 | TEK (0.68) | PDE10ATEKAURKBAURKATPX2 | |
| SCHEMBL974421 | 0.86 | TEK (0.76) | PDE10ATEKAURKBAURKATPX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7868177-B2 | Multi-cyclic compounds and method of use | AMGEN INC. (US) | 2011-01-11 | — | — | US | claimed |
| EP-1994030-B1 | MULTI-CYCLIC COMPOUNDS AND METHOD OF USE | AMGEN INC (US) | 2010-08-25 | — | — | EP | claimed |
| EP-1994030-A1 | MULTI-CYCLIC COMPOUNDS AND METHOD OF USE | Amgen Inc. (US) | 2008-11-26 | — | — | EP | claimed |
| WO-2007100646-A1 | MULTI-CYCLIC COMPOUNDS AND METHOD OF USE | AMGEN INC. (US) | 2007-09-07 | — | — | WO | claimed |
| EP-1994030-B1 | MULTI-CYCLIC COMPOUNDS AND METHOD OF USE | AMGEN INC (US) | 2010-08-25 | — | — | EP | disclosed |