Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HCN4 | Q9Y3Q4 | 3/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9740144 | 0.85 | HCN4 (0.40) | SMN1; SMN2GAAHCN4CHRM2HTR1A | |
| Hydrochloric Acid SCHEMBL9740807 | 0.84 | HCN4 (0.39) | SMN1; SMN2GAAHCN4CHRM2HTR1A | |
| SCHEMBL9739448 | 0.84 | SMN1; SMN2 (0.39) | SMN1; SMN2GAAHCN4CHRM2HTR1A | |
| SCHEMBL9742929 | 0.83 | SMN1; SMN2 (0.38) | SMN1; SMN2GAAHCN4CHRM2HTR1A | |
| SCHEMBL9740863 | 0.82 | HRH3 (0.41) | SMN1; SMN2GAAHCN4CHRM2HTR1A | |
| SCHEMBL9739539 | 0.82 | HCN4 (0.43) | SMN1; SMN2GAAHCN4CHRM2HTR1A | |
| Hydrochloric Acid SCHEMBL9740703 | 0.82 | HRH3 (0.41) | SMN1; SMN2GAAHCN4CHRM2HTR1A | |
| SCHEMBL9740542 | 0.80 | GAA (0.42) | SMN1; SMN2GAAHCN4CHRM2HTR1A | |
| SCHEMBL10719224 | 0.79 | HCN4 (0.41) | SMN1; SMN2GAAHCN4CHRM2HTR1A | |
| Hydrochloric Acid SCHEMBL9741326 | 0.79 | GAA (0.44) | SMN1; SMN2GAAHCN4CHRM2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5175157-A | Cardiovascular disorders | BOEHRINGER INGELHEIM GMBH (DE) | 1992-12-29 | — | — | US | disclosed |
| EP-0224794-A2 | Cyclic amine derivatives, medicines containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1987-06-10 | — | — | EP | disclosed |