Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.41 |
| ▸ | HCN4 | Q9Y3Q4 | 2/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9740703 | 0.99 | HRH3 (0.41) | HRH3HCN4CHRM2HTR1ASLC6A4 | |
| SCHEMBL9740144 | 0.97 | HCN4 (0.40) | HRH3HCN4CHRM2HTR1ASLC6A4 | |
| Hydrochloric Acid SCHEMBL9740807 | 0.97 | HCN4 (0.39) | HRH3HCN4CHRM2HTR1ASLC6A4 | |
| SCHEMBL10719224 | 0.94 | HCN4 (0.41) | HCN4CHRM2HTR1ASLC6A4DRD3 | |
| SCHEMBL9739448 | 0.85 | SMN1; SMN2 (0.39) | HCN4CHRM2HTR1ASLC6A4DRD3 | |
| Hydrochloric Acid SCHEMBL9740789 | 0.84 | KDM4E (0.48) | HRH3ABCB1HRH1CYP3A4ALOX15 | |
| SCHEMBL9207185 | 0.83 | HTR1A (0.37) | HRH3HTR1ADRD3SMN1; SMN2 | |
| SCHEMBL9742929 | 0.83 | SMN1; SMN2 (0.38) | HCN4CHRM2HTR1ASLC6A4DRD3 | |
| SCHEMBL10373619 | 0.83 | ABCB1 (0.51) | HRH3HCN4CHRM2HTR1ASLC6A4 | |
| SCHEMBL9741685 | 0.82 | SMN1; SMN2 (0.37) | HCN4CHRM2HTR1ASLC6A4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5175157-A | Cardiovascular disorders | BOEHRINGER INGELHEIM GMBH (DE) | 1992-12-29 | — | — | US | disclosed |
| EP-0224794-B1 | CYCLIC AMINE DERIVATIVES, MEDICINES CONTAINING THESE COMPOUNDS AND PROCESS FOR THEIR PREPARATION | Dr. Karl Thomae GmbH (DE) | 1990-09-12 | — | — | EP | disclosed |
| EP-0224794-A2 | Cyclic amine derivatives, medicines containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1987-06-10 | — | — | EP | disclosed |