Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 5/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 6/20 | 0.33 |
| ▸ | DRD2 | P14416 | 2/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | PIK3R1 | P27986 | 4/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.30 |
| ▸ | HTR1A | P08908 | 1/20 | 0.30 |
| ▸ | HTR2B | P41595 | 1/20 | 0.30 |
| ▸ | MTOR | P42345 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9868201 | 0.85 | DRD3 (0.49) | DRD3DRD2DRD4 | |
| SCHEMBL9742829 | 0.81 | CNR2 (0.32) | PIK3CAPIK3CBDRD3 | |
| Hydrochloric Acid SCHEMBL9651222 | 0.77 | DRD3 (0.35) | DRD3CHRM2HTR1AHTR2B | |
| Hydrochloric Acid SCHEMBL9641424 | 0.77 | CNR2 (0.44) | DRD3CHRM2HTR1AHTR2B | |
| Hydrochloric Acid SCHEMBL10744957 | 0.76 | PDE10A (0.40) | DRD3DRD2CHRM2HTR1AHTR2B | |
| SCHEMBL9640697 | 0.75 | DRD3 (0.35) | DRD3CHRM2HTR1AHTR2B | |
| SCHEMBL13093625 | 0.75 | CNR2 (0.45) | DRD3CHRM2HTR1AHTR2B | |
| SCHEMBL12363949 | 0.75 | CNR2 (0.45) | DRD3CHRM2HTR1AHTR2B | |
| SCHEMBL9641992 | 0.75 | CNR2 (0.45) | DRD3CHRM2HTR1AHTR2B | |
| SCHEMBL10744679 | 0.74 | PDE10A (0.41) | DRD3DRD2CHRM2HTR1AHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5124328-A | Animal growth antidepressants regulators | MERCK & CO., INC. (US) | 1992-06-23 | — | — | US | claimed |
| US-5124328-A | Animal growth antidepressants regulators | MERCK & CO., INC. (US) | 1992-06-23 | — | — | US | disclosed |
| US-5077290-A | Animal growth regulators, bronchodilators, antidepressants and antiobesity agents | MERCK & CO., INC. (US) | 1991-12-31 | — | — | US | disclosed |