Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.58 |
| ▸ | MEN1 | O00255 | 6/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.57 |
| ▸ | FLT1 | P17948 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
| ▸ | TEK | Q02763 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.47 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.47 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9742582 | 0.84 | MAPT (0.60) | MAPTMEN1KMT2AALDH1A1NPSR1 | |
| SCHEMBL11403139 | 0.82 | MAPK14 (0.63) | MAPTMEN1KMT2AALDH1A1NPSR1 | |
| SCHEMBL12991482 | 0.81 | MEN1 (0.58) | MAPTMEN1KMT2AALDH1A1NPSR1 | |
| SCHEMBL9744026 | 0.81 | MAPT (0.58) | MAPTMEN1KMT2AALDH1A1NPSR1 | |
| SCHEMBL9742264 | 0.80 | ALDH1A1 (0.42) | MAPTMEN1KMT2AALDH1A1NPSR1 | |
| SCHEMBL18884070 | 0.77 | MEN1 (0.54) | MAPTMEN1KMT2AALDH1A1NPSR1 | |
| SCHEMBL20078217 | 0.77 | ALDH1A1 (0.54) | MAPTMEN1KMT2AALDH1A1NPSR1 | |
| SCHEMBL4770175 | 0.77 | MEN1 (0.59) | MAPTMEN1KMT2AALDH1A1NPSR1 | |
| SCHEMBL18878417 | 0.77 | MAPT (0.54) | MAPTMEN1KMT2AALDH1A1NPSR1 | |
| SCHEMBL9748155 | 0.76 | MAPK14 (0.76) | MAPTMEN1KMT2AALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0203787-B1 | Process for preparing pyridyl-substituted imidazo[2,1-b]thiazoles and thiazines | SMITHKLINE BEECHAM CORPORATION (US) | 1992-12-30 | — | — | EP | disclosed |
| US-5008390-A | Compounds for preparing 6-phenyl-2,3-dihydroimidazo[2,1-b]-thiazoles and corresponding thiazines | SMITHKLINE BECKMAN CORPORATION (US) | 1991-04-16 | — | — | US | disclosed |
| US-4803279-A | 1.4-dihydro-4-pyridyl-substituted imidazo (2,1-b) thiazoles and the corresponding thiazines. | SMITHKLINE BECKMAN CORPORATION (US) | 1989-02-07 | — | — | US | disclosed |
| EP-0203787-A2 | Process for preparing pyridyl-substituted imidazo[2,1-b]thiazoles and thiazines | SMITHKLINE BEECHAM CORPORATION (US) | 1986-12-03 | — | — | EP | disclosed |