Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYGL | P06737 | 5/20 | 0.39 |
| ▸ | PYGM | P11217 | 5/20 | 0.39 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 5/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.36 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.36 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4826771 | 0.74 | PTK2B (0.47) | PYGLPYGMPTK2BMAPTRIPK1 | |
| SCHEMBL16313799 | 0.72 | NPC1 (0.45) | PYGLPYGMMAPTRIPK1NPC1 | |
| SCHEMBL2604338 | 0.72 | NPC1 (0.45) | PYGLPYGMMAPTRIPK1NPC1 | |
| SCHEMBL9744419 | 0.70 | — | — | |
| SCHEMBL1270022 | 0.67 | NPC1 (0.52) | PYGLPYGMPTK2BMAPTNPC1 | |
| SCHEMBL1270418 | 0.67 | NPC1 (0.52) | PYGLPYGMPTK2BMAPTNPC1 | |
| SCHEMBL1269652 | 0.67 | NPC1 (0.52) | PYGLPYGMPTK2BMAPTNPC1 | |
| SCHEMBL13904707 | 0.67 | NPC1 (0.52) | PYGLPYGMPTK2BMAPTNPC1 | |
| SCHEMBL29415830 | 0.67 | NPC1 (0.52) | PYGLPYGMPTK2BMAPTNPC1 | |
| SCHEMBL30491873 | 0.67 | BRD4 (0.39) | PYGLPYGMMAPTIDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992016524-A1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1992-10-01 | — | — | WO | disclosed |