Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 1.00 |
| ▸ | NPC1 | O15118 | 8/20 | 1.00 |
| ▸ | RAB9A | P51151 | 8/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 1.00 |
| ▸ | MEN1 | O00255 | 7/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.72 |
| ▸ | GAA | P10253 | 2/20 | 0.72 |
| ▸ | GFER | P55789 | 1/20 | 0.72 |
| ▸ | TP53 | P04637 | 1/20 | 0.71 |
| ▸ | GLA | P06280 | 1/20 | 0.71 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.71 |
| ▸ | LMNA | P02545 | 2/20 | 0.67 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.67 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.67 |
| ▸ | RELA | Q04206 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.62 |
| ▸ | NSD2 | O96028 | 1/20 | 0.62 |
| ▸ | ALPL | P05186 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9744176 | 0.84 | MAPT (0.72) | MAPTNPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL9742712 | 0.84 | MAPT (0.72) | MAPTNPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL9742689 | 0.83 | MAPT (1.00) | MAPTNPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL3202839 | 0.81 | MAPT (0.71) | MAPTNPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL9738237 | 0.80 | MAPT (0.67) | MAPTNPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL14062036 | 0.79 | MAPT (0.64) | MAPTNPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL13856561 | 0.77 | MAPT (1.00) | MAPTNPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL4424341 | 0.77 | KMT2A (0.70) | MAPTNPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL8086759 | 0.75 | NPC1 (0.60) | MAPTNPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL10562991 | 0.75 | MEN1 (1.00) | MAPTNPC1RAB9ASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0203787-B1 | Process for preparing pyridyl-substituted imidazo[2,1-b]thiazoles and thiazines | SMITHKLINE BEECHAM CORPORATION (US) | 1992-12-30 | — | — | EP | disclosed |
| US-5008390-A | Compounds for preparing 6-phenyl-2,3-dihydroimidazo[2,1-b]-thiazoles and corresponding thiazines | SMITHKLINE BECKMAN CORPORATION (US) | 1991-04-16 | — | — | US | disclosed |
| US-4803279-A | 1.4-dihydro-4-pyridyl-substituted imidazo (2,1-b) thiazoles and the corresponding thiazines. | SMITHKLINE BECKMAN CORPORATION (US) | 1989-02-07 | — | — | US | disclosed |
| EP-0203787-A2 | Process for preparing pyridyl-substituted imidazo[2,1-b]thiazoles and thiazines | SMITHKLINE BEECHAM CORPORATION (US) | 1986-12-03 | — | — | EP | disclosed |