Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of L-Alaninol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | GABRP | O00591 | 2/20 | 0.32 |
| ▸ | GABRD | O14764 | 2/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.32 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.32 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.32 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.32 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.32 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.32 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.32 |
| ▸ | GABRE | P78334 | 2/20 | 0.32 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.32 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.32 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.32 |
| ▸ | GABRQ | Q9UN88 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| L-Alaninol SCHEMBL1343064 | 0.80 | TP53 (0.52) | TP53TSHRGABRPGABRDGABRA1 | |
| L-Alaninol SCHEMBL9744342 | 0.80 | — | — | |
| L-Alaninol SCHEMBL11142156 | 0.78 | TP53 (0.44) | TP53TSHRGABRPGABRDGABRA1 | |
| L-Alaninol SCHEMBL30417235 | 0.76 | — | — | |
| L-Alaninol SCHEMBL72189 | 0.76 | — | — | |
| L-Alaninol SCHEMBL1331749 | 0.76 | — | — | |
| L-Alaninol SCHEMBL30499 | 0.76 | — | — | |
| L-Alaninol SCHEMBL82137 | 0.76 | — | — | |
| L-Alaninol SCHEMBL2804901 | 0.76 | TSHR (0.54) | TP53TSHRGABRPGABRDGABRA1 | |
| L-Alaninol SCHEMBL7787362 | 0.76 | TSHR (0.54) | TP53TSHRGABRPGABRDGABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5142075-A | Anti-tumor platinum(II) complexes and process for the preparation thereof | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 1992-08-25 | — | — | US | disclosed |