Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.55 |
| ▸ | HTR7 | P34969 | 2/20 | 0.55 |
| ▸ | HTR2A | P28223 | 1/20 | 0.55 |
| ▸ | DRD2 | P14416 | 1/20 | 0.55 |
| ▸ | CYP19A1 | P11511 | 10/20 | 0.47 |
| ▸ | AXL | P30530 | 1/20 | 0.47 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.47 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.47 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.47 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27709119 | 0.80 | CYP19A1 (0.54) | HTR1AHTR7HTR2ADRD2CYP19A1 | |
| SCHEMBL8127700 | 0.77 | RAB9A (0.50) | HTR1AHTR7HTR2ADRD2CYP19A1 | |
| SCHEMBL9090840 | 0.75 | CYP19A1 (0.61) | CYP19A1AXLPBRM1MKNK1MKNK2 | |
| SCHEMBL9090845 | 0.75 | CYP19A1 (0.61) | CYP19A1AXLPBRM1MKNK1MKNK2 | |
| SCHEMBL27709169 | 0.74 | CYP19A1 (0.52) | CYP19A1AXLPBRM1MKNK1MKNK2 | |
| SCHEMBL9571662 | 0.70 | CYP19A1 (0.67) | CYP19A1AXLPBRM1MKNK1MKNK2 | |
| SCHEMBL10022327 | 0.69 | CYP19A1 (0.61) | CYP19A1AXLPBRM1MKNK1MKNK2 | |
| Bromide SCHEMBL9342058 | 0.69 | CYP19A1 (0.65) | CYP19A1AXLPBRM1MKNK1MKNK2 | |
| SCHEMBL2759638 | 0.67 | CYP19A1 (0.61) | CYP19A1AXLPBRM1MKNK1MKNK2 | |
| SCHEMBL7998302 | 0.66 | MAPK1 (0.63) | CYP19A1AXLPBRM1MKNK1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5171746-A | THIAZOLE AND IMIDAZOLE DERIVATIVES AND ANTIULCER COMPOSITION CONTAINING SAME | MEIJI SEIKA KABUSHIKI KAISHA (JP) | 1992-12-15 | — | — | US | disclosed |
| EP-0452076-A1 | Thiazole and imidazole derivatives and antiulcer composition containing same | MEIJI SEIKA KABUSHIKI KAISHA (JP) | 1991-10-16 | — | — | EP | disclosed |