SCHEMBL9745531

SCHEMBL9745531

COc1ccc(C(N)C(N)c2ccc(OC)c(OC)c2)cc1OC

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACHE P22303 5/20 0.61
PPARG P37231 1/20 0.52
PPARD Q03181 1/20 0.52
PPARA Q07869 1/20 0.52
CA2 P00918 3/20 0.51
CA1 P00915 2/20 0.51
L3MBTL1 Q9Y468 3/20 0.49
CA12 O43570 1/20 0.48
CA7 P43166 1/20 0.48
CA9 Q16790 1/20 0.48
CA14 Q9ULX7 1/20 0.48
TDP1 Q9NUW8 1/20 0.47
CYP1A2 P05177 1/20 0.46
CYP2C9 P11712 1/20 0.46
CYP2C19 P33261 1/20 0.46
KMT2A Q03164 1/20 0.46
NPSR1 Q6W5P4 1/20 0.46
HTR3E A5X5Y0 1/20 0.44
HTR3B O95264 1/20 0.44
HTR3A P46098 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10866646 0.92 ACHE (0.54) ACHEPPARGPPARDPPARACA2
SCHEMBL10781197 0.90 ACHE (0.57) ACHEPPARGPPARDPPARACA2
SCHEMBL8203270 0.90 ACHE (0.56) ACHEPPARGPPARDPPARACA2
Hydrochloric Acid SCHEMBL5138937 0.88 ACHE (0.54) ACHEPPARGPPARDPPARACA2
SCHEMBL5283320 0.86 ACHE (0.74) ACHEPPARGPPARDPPARACA2
SCHEMBL1719900 0.84 ACHE (0.54) ACHEPPARGPPARDPPARACA2
SCHEMBL29975311 0.84 ACHE (0.54) ACHEPPARGPPARDPPARACA2
SCHEMBL3635226 0.84 ACHE (0.54) ACHEPPARGPPARDPPARACA2
SCHEMBL3976767 0.84 ACHE (0.54) ACHEPPARGPPARDPPARACA2
SCHEMBL10865644 0.84 ACHE (0.51) ACHEPPARGPPARDPPARACA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5100877-A Chemotherapy, anticancer agents, improved water solubility, side effect reduction KURARAY CO., LTD. (JP) 1992-03-31 US disclosed
US-4948784-A ANTICARCINOGENIC AND-TUMOR AGENTS; WATER-SOLUBEL MACROMOLICULAR COMPLEXES; SIDE EFFECT REDUCTION KURARAY COMPANY, LTD. (JP) 1990-08-14 US disclosed
EP-0307827-A2 Novel macromolecular complexes, process for producing same and medicinal use of such complexes KURARAY CO., LTD. (JP) 1989-03-22 EP disclosed
EP-0270682-A1 NOVEL COMPLEXES, PROCESS FOR THEIR PREPARATION, AND MEDICINAL USE OF THEM KURARAY CO., LTD. (JP) 1988-06-15 EP disclosed
EP-0116955-B1 COMPLEXES OF (1,2-DIPHENYL-ETHYLENE DIAMINE) PLATINUM (II) Degussa Aktiengesellschaft (DE) 1987-05-20 EP disclosed
US-4598091-A (1,2-diphenyl)-ethylenediamine)-platinum (II) complex compounds DEGUSSA AKTIENGESELLSCHAFT (DE) 1986-07-01 US disclosed
EP-0116955-A2 Complexes of (1,2-diphenyl-ethylene diamine) platinum (II) Degussa Aktiengesellschaft (DE) 1984-08-29 EP disclosed