SCHEMBL9745862

SCHEMBL9745862

CCOC(=O)C1=C(C)NC(/C=C/c2ccccc2)=C(C(=O)OCC)C1c1ccccc1C(F)(F)CF

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA3 P0DMS8 2/20 0.49
KDM4E B2RXH2 1/20 0.49
MEN1 O00255 1/20 0.49
ALDH1A1 P00352 1/20 0.49
MAPT P10636 1/20 0.49
HPGD P15428 1/20 0.49
XBP1 P17861 1/20 0.49
KMT2A Q03164 1/20 0.49
L3MBTL1 Q9Y468 1/20 0.49
CACNA1C Q13936 2/20 0.46
CACNA1F O60840 1/20 0.46
CACNA1D Q01668 1/20 0.46
CACNA1S Q13698 1/20 0.46
LMNA P02545 1/20 0.46
HTT P42858 1/20 0.46
NR1I2 O75469 1/20 0.46
PGR P06401 1/20 0.46
CYP3A4 P08684 1/20 0.46
CYP2C9 P11712 1/20 0.46
SLC6A2 P23975 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9744605 0.91 CACNA1C (0.56) CACNA1CCACNA1FCACNA1DCACNA1S
SCHEMBL9744612 0.91 CACNA1C (0.56) CACNA1CCACNA1FCACNA1DCACNA1S
SCHEMBL9745864 0.83 ADORA3 (0.53) ADORA3KDM4EMEN1ALDH1A1MAPT
SCHEMBL9744949 0.80 ADORA3 (0.53) ADORA3KDM4EMEN1ALDH1A1MAPT
SCHEMBL9744953 0.80 ADORA3 (0.53) ADORA3KDM4EMEN1ALDH1A1MAPT
SCHEMBL7374095 0.79 CACNA1C (0.60) CACNA1CCACNA1FCACNA1DCACNA1S
SCHEMBL9744963 0.78 ADORA3 (0.56) ADORA3KDM4EMEN1ALDH1A1MAPT
SCHEMBL7431826 0.77 CACNA1C (0.71) CACNA1CCACNA1FCACNA1DCACNA1S
SCHEMBL7380935 0.76 CACNA1C (0.57) CACNA1CCACNA1FCACNA1DCACNA1S
SCHEMBL7379516 0.76 CACNA1C (0.54) CACNA1CCACNA1FCACNA1DCACNA1S

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0215250-B1 2-SUBSTITUTED-1,4-DIHYDROPYRIDINES, METHOD FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) 1992-12-30 EP claimed