Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | GMNN | O75496 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9744641 | 0.81 | CACNA1C (0.52) | PDE4DMAPTCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL9744636 | 0.81 | CACNA1C (0.52) | PDE4DMAPTCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL9745284 | 0.78 | KMT2A (0.37) | PDE4BPDE4DMAPTCYP1A2CYP3A4 | |
| SCHEMBL9744737 | 0.76 | CACNA1C (0.56) | PDE4BPDE4DMAPTCYP1A2CYP3A4 | |
| SCHEMBL9745985 | 0.76 | HIF1A (0.55) | MAPTCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL10515946 | 0.75 | CYP1A2 (0.62) | PDE4BPDE4DMAPTCYP1A2CYP3A4 | |
| SCHEMBL9191537 | 0.72 | HIF1A (0.61) | MAPTCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL9192866 | 0.72 | HIF1A (0.61) | MAPTCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL9198844 | 0.72 | HIF1A (0.59) | MAPTCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL9787318 | 0.71 | HIF1A (0.59) | MAPTCYP1A2CYP3A4CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0215250-B1 | 2-SUBSTITUTED-1,4-DIHYDROPYRIDINES, METHOD FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1992-12-30 | — | — | EP | disclosed |
| US-4845113-A | USEFUL IN RADICAL SCAVENGING THERAPY | BOEHRINGER BIOCHEMIA ROBIN S.P.A. (IT) | 1989-07-04 | — | — | US | disclosed |
| EP-0215250-A1 | 2-Substituted-1,4-dihydropyridines, method for their preparation and pharmaceutical compositions containing them | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1987-03-25 | — | — | EP | disclosed |